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The role of kappa-opioid receptor activation in mediating antinociception and addiction

文献类型：期刊论文

作者Wang, Yu-hua1,2; Sun, Jian-feng1; Tao, Yi-min1; Chi, Zhi-qiang1; Liu, Jing-gen1
刊名ACTA PHARMACOLOGICA SINICA
出版日期2010-09
卷号31期号:9页码:1065-1070
关键词kappa-opioid receptor dynorphin desensitization antinociception tolerance addiction drug withdrawal cocaine reward negative mood state
ISSN号1671-4083
DOI10.1038/aps.2010.138
文献子类Review
英文摘要The kappa-opioid receptor (KOR), a member of the opioid receptor family, is widely expressed in the central nervous system and peripheral tissues. Substantial evidence has shown that activation of KOR by agonists and endogenous opioid peptides in vivo may produce a strong analgesic effect that is free from the abuse potential and the adverse side effects of mu-opioid receptor (MOR) agonists, such as morphine. In addition, activation of the KOR has also been shown to exert an inverse effect on morphine-induced adverse actions, such as tolerance, reward, and impairment of learning and memory. Therefore, the KOR has received much attention in the effort to develop alternative analgesics to MOR agonists and agents for the treatment of drug addiction. However, KOR agonists also produce several severe undesirable side effects such as dysphoria, water diuresis, salivation, emesis, and sedation in nonhuman primates, which may limit the clinical utility of KOR agonists for pain and drug abuse treatment. This article will review the role of KOR activation in mediating antinociception and addiction. The possible therapeutic application of kappa-agonists in the treatment of pain and drug addiction is also discussed.
WOS关键词CONDITIONED PLACE PREFERENCE ; ROSTRAL VENTROMEDIAL MEDULLA ; AGONIST SALVINORIN-A ; COCAINE-SEEKING ; RHESUS-MONKEYS ; PHARMACOLOGICAL CHARACTERIZATION ; INDUCED REINSTATEMENT ; PERIAQUEDUCTAL GRAY ; OPIATE WITHDRAWAL ; SELECTIVE AGONIST
资助项目Ministry of Science and Technology of China[2009CB522000] ; Ministry of Science and Technology of China[2009ZX09301-001] ; National Natural Science Fundation of China[30873050] ; Chinese Academy of Sciences[KSCX2-YW-R-253]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
CSCD记录号CSCD:3989606
WOS记录号WOS:000281562900010
出版者ACTA PHARMACOLOGICA SINICA
源URL[http://119.78.100.183/handle/2S10ELR8/278781]  
专题药理学第二研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Liu, Jing-gen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210046, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yu-hua,Sun, Jian-feng,Tao, Yi-min,et al. The role of kappa-opioid receptor activation in mediating antinociception and addiction[J]. ACTA PHARMACOLOGICA SINICA,2010,31(9):1065-1070.
APA Wang, Yu-hua,Sun, Jian-feng,Tao, Yi-min,Chi, Zhi-qiang,&Liu, Jing-gen.(2010).The role of kappa-opioid receptor activation in mediating antinociception and addiction.ACTA PHARMACOLOGICA SINICA,31(9),1065-1070.
MLA Wang, Yu-hua,et al."The role of kappa-opioid receptor activation in mediating antinociception and addiction".ACTA PHARMACOLOGICA SINICA 31.9(2010):1065-1070.

入库方式： OAI收割

来源：上海药物研究所

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