Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus
文献类型：期刊论文
| 作者 | Luo, Yu2; Yao, Jia-Ping2; Yang, Li1; Feng, Chun-Lan1; Tang, Wei1 ; Wang, Gui-Feng1; Zuo, Jian-Pin1; Lu, Wei2
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2010-07-15 |
| 卷号 | 18期号:14页码:5048-5055 |
| 关键词 | Benzimidazoles Anti-HBV activity |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2010.05.076 |
| 文献子类 | Article |
| 英文摘要 | A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50 < 0.41 mu M and SI > 81.2, was the most promising compound and selected as the benchmark compound for further optimization. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | C-VIRUS ; NS5B POLYMERASE ; IN-VITRO ; RECEPTOR ; IDENTIFICATION ; DISCOVERY ; POTENT ; ACIDS ; REPLICATION ; ESTERS |
| 资助项目 | National Basic Research Program of China[30701033] ; Shanghai Natural Science Foundation[09ZR1438100] ; Chinese Academy of Sciences[SIMM0909 KF-08] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000279744700022 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278830]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zuo, Jian-Pin |
| 作者单位 | 1.Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Yu,Yao, Jia-Ping,Yang, Li,et al. Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(14):5048-5055. |
| APA | Luo, Yu.,Yao, Jia-Ping.,Yang, Li.,Feng, Chun-Lan.,Tang, Wei.,...&Lu, Wei.(2010).Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus.BIOORGANIC & MEDICINAL CHEMISTRY,18(14),5048-5055. |
| MLA | Luo, Yu,et al."Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus".BIOORGANIC & MEDICINAL CHEMISTRY 18.14(2010):5048-5055. |
入库方式： OAI收割
来源：上海药物研究所
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