Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors
文献类型：期刊论文
| 作者 | Shi, Jianyou1,2,3; Xu, Guobin1,2; Zhu, Wei1,2; Ye, Haoyu1,2; Yang, Shengyong1,2; Luo, Youfu1,2; Han, Jing1,2; Yang, Jincheng1,2,3; Li, Rui1,2,4; Wei, Yuquan1,2 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2010-07-15 |
| 卷号 | 20期号:14页码:4273-4278 |
| 关键词 | 1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles Pyrazolo[3,4-b]pyridines Antitumor Aurora-A kinase |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2010.04.083 |
| 文献子类 | Article |
| 英文摘要 | Two series of 3-aminopyrazole compounds including 24 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and 16 pyrazolo[3,4-b]pyridines were synthesized and evaluated against HCT116, A549, and A2780 tumor cell lines. Among them, three compounds were found to have the ideal anti-proliferative activities in vitro. Docking experiments showed that the novel pyrazolo[3,4-b]pyridines share the similar interaction mode with Aurora-A kinase as PHA739358. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | POTENT ; DISCOVERY ; PROFILE |
| 资助项目 | National Program of China[2009ZX09501-015] ; National Science Foundation of China[30901743] ; State Key Laboratory of Drug Research[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000279258800063 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278833]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Li, Rui |
| 作者单位 | 1.Sichuan Univ, W China Med Sch, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; 2.Sichuan Univ, W China Med Sch, W China Hosp, Ctr Canc, Chengdu 610041, Sichuan, Peoples R China; 3.Sichuan Univ, Pharm Coll W China, Chengdu 610065, Sichuan, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Jianyou,Xu, Guobin,Zhu, Wei,et al. Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(14):4273-4278. |
| APA | Shi, Jianyou.,Xu, Guobin.,Zhu, Wei.,Ye, Haoyu.,Yang, Shengyong.,...&Chen, Lijuan.(2010).Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(14),4273-4278. |
| MLA | Shi, Jianyou,et al."Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.14(2010):4273-4278. |
入库方式： OAI收割
来源：上海药物研究所
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