Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells
文献类型：期刊论文
| 作者 | Wang, Guo-Fei1; Guo, Yue-Wei2 ; Feng, Bo1; Li, Liang2; Huang, Cai-Guo1; Jiao, Bing-Hua1
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| 刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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| 出版日期 | 2010-07 |
| 卷号 | 30期号:1页码:31-36 |
| 关键词 | Tanghinigenin Apoptosis Fas FasL HL-60 Caspase |
| ISSN号 | 1382-6689 |
| DOI | 10.1016/j.etap.2010.03.012 |
| 文献子类 | Article |
| 英文摘要 | Tanghinigenin, a cardiac glycoside, is isolated from the seeds of Cerbera manghas L In this study, we demonstrated that tanghinigenin reduced the viability of human promyelocytic leukemia HL-60 cells in a time- and dose-dependent manner, and efficiently induced apoptosis in HL-60 cells as evidenced by the Annexin V/PI binding assay, DNA fragmentation and AO/EB staining studies. In addition, stimulation of HL-60 cells with tanghinigenin induced a series of intracellular events including the activation of caspase-3, -8, and -9, as well as up-regulation of Fas and FasL protein level. Taken together, caspase activation and Fas/FasL interaction was found to be involved in tanghinigenin-induced HL-60 cell apoptosis. (C) 2010 Elsevier B.V. All rights reserved. |
| WOS关键词 | DRUG-INDUCED APOPTOSIS ; APO-1/FAS RECEPTOR/LIGAND SYSTEM ; INDUCED-PROXIMITY MODEL ; ACTIVATION ; FAS ; PROLIFERATION ; CASPASE-8 ; OUABAIN ; LIGAND ; CANCER |
| 资助项目 | National Basic Research Program of China (973 Program)[2010CB833804] |
| WOS研究方向 | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000279089000006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278853]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 上海药物代谢研究中心 |
| 通讯作者 | Huang, Cai-Guo |
| 作者单位 | 1.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Guo-Fei,Guo, Yue-Wei,Feng, Bo,et al. Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2010,30(1):31-36. |
| APA | Wang, Guo-Fei,Guo, Yue-Wei,Feng, Bo,Li, Liang,Huang, Cai-Guo,&Jiao, Bing-Hua.(2010).Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,30(1),31-36. |
| MLA | Wang, Guo-Fei,et al."Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 30.1(2010):31-36. |
入库方式： OAI收割
来源：上海药物研究所
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