Plasma Lp-PLA(2) in Acute Coronary Syndrome: Association with Major Adverse Cardiac Events in a Community-Based Cohort
文献类型：期刊论文
| 作者 | Li, Ning1; Li, Shuijun2,3; Yu, Chen2; Gu, Shuiming1 |
| 刊名 | POSTGRADUATE MEDICINE
 |
| 出版日期 | 2010-07 |
| 卷号 | 122期号:4页码:200-205 |
| 关键词 | acute coronary syndrome coronary artery disease major adverse cardiac events lipoprotein-associated phospholipase A(2) |
| ISSN号 | 0032-5481 |
| DOI | 10.3810/pgm.2010.07.2187 |
| 文献子类 | Article |
| 英文摘要 | Objective: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a useful inflammatory marker of cardiovascular risk, yet there are few reports on the prognostic significance of Lp-PLA(2) as a risk factor for acute coronary syndrome (ACS). It is necessary to evaluate the association of Lp-PLA(2) with major adverse cardiac events (MACE) in patients with ACS and assess its incremental value for risk discrimination over established risk factors and biomarkers. Methods: One hundred fifty-two patients with ACS and 142 patients without coronary artery disease (CAD) from Shanghai Xuhui District, PRC (aged < 80 years) were enrolled from February 2007 to March 2008 and were followed for a median of 6 months (range, 4-10 months). Plasma Lp-PLA(2) activity was measured at baseline with liquid chromatography tandem mass spectrometry. Its clinical significance was evaluated with existing risk indicators. Results: Lp-PLA(2) activity was higher in patients with ACS than in patients without CAD (22.36 +/- 1.23 mg/mL vs 19.74 +/- 3.85 mg/mL; P = 0.027). During the follow-up period, 5 cases of cardiovascular death, 8 cases of nonfatal myocardial infarction, and 11 cases of target vessel revascularization occurred. Elevated Lp-PLA(2) was associated with an increased risk of MACE (hazard ratio, 1.52; 95% confidence interval, 1.09-2.37; P = 0.033). The Lp-PLA(2) activity level in incidental cases was higher than in nonincidental cases (P = 0.04). Conclusion: In this community-based cohort of patients with ACS, Lp-PLA(2) was strongly and independently associated with major adverse cardiac events and contributed incrementally to risk discrimination. |
| WOS关键词 | ACTIVATING-FACTOR ACETYLHYDROLASE ; C-REACTIVE PROTEIN ; MIDDLE-AGED MEN ; PHOSPHOLIPASE A(2) ; HEART-DISEASE ; LIPOPROTEIN ; RISK ; ATHEROSCLEROSIS |
| 资助项目 | Shanghai Health Bureau[05II028] ; government of Xuhui District, Shanghai, PRC[00000000] |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000286614200018 |
| 出版者 | JTE MULTIMEDIA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278867]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Gu, Shuiming |
| 作者单位 | 1.Shanghai Xuhui Cent Hosp, Dept Cardiol, Shanghai 200033, Peoples R China; 2.Shanghai Xuhui Cent Hosp, Cent Lab, Shanghai 200033, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ning,Li, Shuijun,Yu, Chen,et al. Plasma Lp-PLA(2) in Acute Coronary Syndrome: Association with Major Adverse Cardiac Events in a Community-Based Cohort[J]. POSTGRADUATE MEDICINE,2010,122(4):200-205. |
| APA | Li, Ning,Li, Shuijun,Yu, Chen,&Gu, Shuiming.(2010).Plasma Lp-PLA(2) in Acute Coronary Syndrome: Association with Major Adverse Cardiac Events in a Community-Based Cohort.POSTGRADUATE MEDICINE,122(4),200-205. |
| MLA | Li, Ning,et al."Plasma Lp-PLA(2) in Acute Coronary Syndrome: Association with Major Adverse Cardiac Events in a Community-Based Cohort".POSTGRADUATE MEDICINE 122.4(2010):200-205. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。