中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Plasma Lp-PLA(2) in Acute Coronary Syndrome: Association with Major Adverse Cardiac Events in a Community-Based Cohort

文献类型:期刊论文

作者Li, Ning1; Li, Shuijun2,3; Yu, Chen2; Gu, Shuiming1
刊名POSTGRADUATE MEDICINE
出版日期2010-07
卷号122期号:4页码:200-205
关键词acute coronary syndrome coronary artery disease major adverse cardiac events lipoprotein-associated phospholipase A(2)
ISSN号0032-5481
DOI10.3810/pgm.2010.07.2187
文献子类Article
英文摘要Objective: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a useful inflammatory marker of cardiovascular risk, yet there are few reports on the prognostic significance of Lp-PLA(2) as a risk factor for acute coronary syndrome (ACS). It is necessary to evaluate the association of Lp-PLA(2) with major adverse cardiac events (MACE) in patients with ACS and assess its incremental value for risk discrimination over established risk factors and biomarkers. Methods: One hundred fifty-two patients with ACS and 142 patients without coronary artery disease (CAD) from Shanghai Xuhui District, PRC (aged < 80 years) were enrolled from February 2007 to March 2008 and were followed for a median of 6 months (range, 4-10 months). Plasma Lp-PLA(2) activity was measured at baseline with liquid chromatography tandem mass spectrometry. Its clinical significance was evaluated with existing risk indicators. Results: Lp-PLA(2) activity was higher in patients with ACS than in patients without CAD (22.36 +/- 1.23 mg/mL vs 19.74 +/- 3.85 mg/mL; P = 0.027). During the follow-up period, 5 cases of cardiovascular death, 8 cases of nonfatal myocardial infarction, and 11 cases of target vessel revascularization occurred. Elevated Lp-PLA(2) was associated with an increased risk of MACE (hazard ratio, 1.52; 95% confidence interval, 1.09-2.37; P = 0.033). The Lp-PLA(2) activity level in incidental cases was higher than in nonincidental cases (P = 0.04). Conclusion: In this community-based cohort of patients with ACS, Lp-PLA(2) was strongly and independently associated with major adverse cardiac events and contributed incrementally to risk discrimination.
WOS关键词ACTIVATING-FACTOR ACETYLHYDROLASE ; C-REACTIVE PROTEIN ; MIDDLE-AGED MEN ; PHOSPHOLIPASE A(2) ; HEART-DISEASE ; LIPOPROTEIN ; RISK ; ATHEROSCLEROSIS
资助项目Shanghai Health Bureau[05II028] ; government of Xuhui District, Shanghai, PRC[00000000]
WOS研究方向General & Internal Medicine
语种英语
WOS记录号WOS:000286614200018
出版者JTE MULTIMEDIA
源URL[http://119.78.100.183/handle/2S10ELR8/278867]  
专题药理学第一研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Gu, Shuiming
作者单位1.Shanghai Xuhui Cent Hosp, Dept Cardiol, Shanghai 200033, Peoples R China;
2.Shanghai Xuhui Cent Hosp, Cent Lab, Shanghai 200033, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714
Li, Ning,Li, Shuijun,Yu, Chen,et al. Plasma Lp-PLA(2) in Acute Coronary Syndrome: Association with Major Adverse Cardiac Events in a Community-Based Cohort[J]. POSTGRADUATE MEDICINE,2010,122(4):200-205.
APA Li, Ning,Li, Shuijun,Yu, Chen,&Gu, Shuiming.(2010).Plasma Lp-PLA(2) in Acute Coronary Syndrome: Association with Major Adverse Cardiac Events in a Community-Based Cohort.POSTGRADUATE MEDICINE,122(4),200-205.
MLA Li, Ning,et al."Plasma Lp-PLA(2) in Acute Coronary Syndrome: Association with Major Adverse Cardiac Events in a Community-Based Cohort".POSTGRADUATE MEDICINE 122.4(2010):200-205.

入库方式: OAI收割

来源:上海药物研究所

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