Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists
文献类型：期刊论文
| 作者 | Du, Yongli1; Li, Qunyi2; Xiong, Bing1 ; Hui, Xin2; Wang, Xin1; Feng, Yang2; Meng, Tao1; Hu, Dingyu1; Zhang, Datong3; Wang, Mingwei1,2
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
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| 出版日期 | 2010-06-15 |
| 卷号 | 18期号:12页码:4255-4268 |
| 关键词 | Progesterone receptor (PR) Progesterone receptor antagonist Non-steroidal progesterone receptor antagonist Aromatic beta-amino-ketone Mannich reaction |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2010.04.092 |
| 文献子类 | Article |
| 英文摘要 | A novel class of non-steroidal progesterone receptor antagonists with aromatic beta-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. Among them, compound 22 was shown to be the most potent progesterone receptor antagonist in cotransfection assay and a murine model of ligand-induced decidualization. (C) 2010 Published by Elsevier Ltd. |
| WOS关键词 | RU-486 ; MODULATORS ; ACTIVATION |
| 资助项目 | Ministry of Science and Technology of China[2009ZX09302-001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000278480900011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278869]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Mingwei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 3.Shandong Inst Light Ind, Sch Chem Engn, Jinan 250353, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Yongli,Li, Qunyi,Xiong, Bing,et al. Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(12):4255-4268. |
| APA | Du, Yongli.,Li, Qunyi.,Xiong, Bing.,Hui, Xin.,Wang, Xin.,...&Shen, Jingkang.(2010).Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.BIOORGANIC & MEDICINAL CHEMISTRY,18(12),4255-4268. |
| MLA | Du, Yongli,et al."Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists".BIOORGANIC & MEDICINAL CHEMISTRY 18.12(2010):4255-4268. |
入库方式： OAI收割
来源：上海药物研究所
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