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Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

文献类型：期刊论文

作者Cho, Tang Peng1; Gang, Lin Zhi1; Long, Yang Fang1; Yang, Wang1; Qian, Wang1; Lei, Zhang1; Jing, Luo Jing1; Ying, Feng2; Ke, Yan Pang1,2; Ying, Leng2
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2010-06-15
卷号20期号:12页码:3521-3525
关键词Bicyclo[3.3.0]octane derivatives Dipeptidyl peptidase 4 Inhibitors Oral glucose tolerance tests Type 2 diabetes
ISSN号0960-894X
DOI10.1016/j.bmcl.2010.04.138
文献子类Article
英文摘要A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests. (C) 2010 Elsevier Ltd. All rights reserved.
WOS关键词IV INHIBITOR ; ANTIHYPERGLYCEMIC PROPERTIES ; POTENT ; GLP-1 ; DISCOVERY
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000278208200014
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/278870]  
专题药理学第一研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Cho, Tang Peng
作者单位1.Shanghai Hengrui Pharmaceut Co Ltd, Shanghai 200245, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Cho, Tang Peng,Gang, Lin Zhi,Long, Yang Fang,et al. Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(12):3521-3525.
APA Cho, Tang Peng.,Gang, Lin Zhi.,Long, Yang Fang.,Yang, Wang.,Qian, Wang.,...&Jun, Feng.(2010).Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(12),3521-3525.
MLA Cho, Tang Peng,et al."Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.12(2010):3521-3525.

入库方式： OAI收割

来源：上海药物研究所

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