Highly alpha-Selective Synthesis of Sialyl Spirohydantoins by Regiospecific Domino Condensation/O -> N Acyl Migration/N-Sialylation of Carbodiimides with Peracetylated Sialic Acid
文献类型：期刊论文
| 作者 | Zhang, Dengyou; Ye, Deju; Feng, Enguang; Wang, Jinfang; Shi, Jianmei; Jiang, Hualiang ; Liu, Hong
|
| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2010-06-04 |
| 卷号 | 75期号:11页码:3552-3557 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/jo100016k |
| 文献子类 | Article |
| 英文摘要 | A novel and efficient process for the synthesis of a-sialyl spirohydantoin analogues via one-pot sequential reaction involving various carbodiimides and peracetylated Neu5Ac is reported. BF(2)center dot Et(2)O mediating intramolecular N-sialylation with excellent cf.-selectivity is first demonstrated. |
| WOS关键词 | ALPHA,BETA-UNSATURATED CARBOXYLIC-ACIDS ; N-ACETYLNEURAMINIC ACID ; ONE-POT SYNTHESIS ; ANTIARRHYTHMIC ACTIVITY ; EFFICIENT SYNTHESIS ; OLIGOSIALIC ACIDS ; DONORS ; THIOSIALOSIDE ; INHIBITION ; HYDANTOINS |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; International Collaboration Projects[20720102040] ; 863 Hi-Tech Program of China[2006AA020602] ; National S&T Major Projects[2009ZX09301-001] ; National S&T Major Projects[2009ZX09501-001] ; National S&T Major Projects[2009ZX09501-010] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000278063100002 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278875]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Dengyou,Ye, Deju,Feng, Enguang,et al. Highly alpha-Selective Synthesis of Sialyl Spirohydantoins by Regiospecific Domino Condensation/O -> N Acyl Migration/N-Sialylation of Carbodiimides with Peracetylated Sialic Acid[J]. JOURNAL OF ORGANIC CHEMISTRY,2010,75(11):3552-3557. |
| APA | Zhang, Dengyou.,Ye, Deju.,Feng, Enguang.,Wang, Jinfang.,Shi, Jianmei.,...&Liu, Hong.(2010).Highly alpha-Selective Synthesis of Sialyl Spirohydantoins by Regiospecific Domino Condensation/O -> N Acyl Migration/N-Sialylation of Carbodiimides with Peracetylated Sialic Acid.JOURNAL OF ORGANIC CHEMISTRY,75(11),3552-3557. |
| MLA | Zhang, Dengyou,et al."Highly alpha-Selective Synthesis of Sialyl Spirohydantoins by Regiospecific Domino Condensation/O -> N Acyl Migration/N-Sialylation of Carbodiimides with Peracetylated Sialic Acid".JOURNAL OF ORGANIC CHEMISTRY 75.11(2010):3552-3557. |
入库方式： OAI收割
来源：上海药物研究所
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