Spiralisones A-D: Acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis
文献类型：期刊论文
| 作者 | Zhang, Hua1,2; Xiao, Xue2; Conte, Melissa M.2; Khalil, Zeinab2; Capon, Robert J.2 |
| 刊名 | Organic and Biomolecular Chemistry
 |
| 出版日期 | 2012 |
| 卷号 | 10期号:48页码:9671-9676 |
| ISSN号 | 14770520 |
| DOI | 10.1039/c2ob26988k |
| 文献子类 | Article |
| 英文摘要 | An intertidal sample of the Australian marine brown alga, Zonaria spiralis, exhibited promising kinase inhibitory and antibacterial activity. Chemical analysis returned six phloroglucinol-derived lipids, the new hemiketal spiralisones A-D (1-4) and the known chromones 5-6, and the known norsesquiterpenoid apo-9′-fucoxanthinone (7). Structures 1-7 were assigned on the basis of detailed spectroscopic analysis, biosynthetic considerations and total synthesis. Spiralisones undergo facile acid-mediated dehydration to yield the corresponding chromones, revealing for the first time that brown algal chromones may be handling artifacts rather than natural products. Hemiketals 1 and 2, and chromone 6, displayed inhibitory activity against the neurodegenerative disease kinase targets CDK5/p25, CK1δ and GSK3β, while hemiketals 1, 3 and 4, and chromone 6, displayed growth inhibitory activity against the Gram-positive bacteria Bacillus subtilis (ATCC 6051 and 6633). The promising kinase inhibitory and antibacterial properties of the Z. spiralis extract were attributed to the cumulative effect of many moderately potent phloroglucinol-derived lipid co-metabolites. |
| 语种 | 英语 |
| 出版者 | Royal Society of Chemistry |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266979]  |
| 专题 | 期刊编辑部 分析化学研究室 |
| 通讯作者 | Capon, Robert J. |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201023, China 2.Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, St. Lucia QLD 4072, Australia; |
| 推荐引用方式 GB/T 7714 | Zhang, Hua,Xiao, Xue,Conte, Melissa M.,et al. Spiralisones A-D: Acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis[J]. Organic and Biomolecular Chemistry,2012,10(48):9671-9676. |
| APA | Zhang, Hua,Xiao, Xue,Conte, Melissa M.,Khalil, Zeinab,&Capon, Robert J..(2012).Spiralisones A-D: Acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis.Organic and Biomolecular Chemistry,10(48),9671-9676. |
| MLA | Zhang, Hua,et al."Spiralisones A-D: Acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis".Organic and Biomolecular Chemistry 10.48(2012):9671-9676. |
入库方式： OAI收割
来源：上海药物研究所
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