DNA or histone epigenetics modification and obesity or diabetes:mechanism and inhibitors
文献类型：期刊论文
| 作者 | Zhang Xinlei3; Liu Xueying2; Zhang Shengyong2; Kong Xiangqian1; Ye Fei1; Luo Cheng1
|
| 刊名 | Chinese Journal of Medicinal Chemistry
 |
| 出版日期 | 2013 |
| 卷号 | 23期号:2页码:148-156 |
| 关键词 | diabetes mellitus epigenetics DNMT inhibitor |
| ISSN号 | 1005-0108 |
| 其他题名 | DNA和组蛋白表观遗传修饰与糖尿病和肥胖的关系以及小分子抑制剂的研究进展 |
| 文献子类 | Review |
| 英文摘要 | Diabetes and obesity are commonly found among metabolic disorders affect patients worldwide. Till now,efforts have been done by researchers for decades. However, the genetic basis and molecular mechanisms were still ambiguous. Recent researchers have claimed the correlations between epigenetic changes and multiple environmental factors which involved in occurrence and development of diabetes and obesity. Epigenetic changes of certain genes may serve as the starting factors of developing diabetes and obesity. In this paper,we summarized those epigenetic targets and their inhibitors which are potentially involved for the obesity and diabetes,and then provided a few clues for preventing and treating these syndromes. |
| 资助项目 | 国家自然科学基金项目[00000000] ; 广东省科技计划项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4833966 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267780]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Luo Cheng |
| 作者单位 | 1.Drug Design & Discovery Center,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica, Shanghai 201203, China. 2.Department of Medicinal Chemistry and Pharmaceutical Analysis,School of Pharmacy,Fourth Military Medical University, Xian, 710032.; 3.Department of Medicinal Chemistry and Pharmaceutical Analysis,School of Pharmacy,Fourth Military Medical University, State Key Laboratory of Drug Research, Xian, 710032.; |
| 推荐引用方式 GB/T 7714 | Zhang Xinlei,Liu Xueying,Zhang Shengyong,et al. DNA or histone epigenetics modification and obesity or diabetes:mechanism and inhibitors[J]. Chinese Journal of Medicinal Chemistry,2013,23(2):148-156. |
| APA | Zhang Xinlei,Liu Xueying,Zhang Shengyong,Kong Xiangqian,Ye Fei,&Luo Cheng.(2013).DNA or histone epigenetics modification and obesity or diabetes:mechanism and inhibitors.Chinese Journal of Medicinal Chemistry,23(2),148-156. |
| MLA | Zhang Xinlei,et al."DNA or histone epigenetics modification and obesity or diabetes:mechanism and inhibitors".Chinese Journal of Medicinal Chemistry 23.2(2013):148-156. |
入库方式： OAI收割
来源：上海药物研究所
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