Progress in the fragment-based drug discovery
文献类型：期刊论文
| 作者 | Ren Jing1; Li Jian2; Shi Feng1; Wang Xin1 ; He Jianhua2; Xu Yechun1; Zhang Naixia1; Xiong Bing1; Shen Jingkang1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2013 |
| 卷号 | 48期号:1页码:14-24 |
| 关键词 | fragment screening optimization drug discovery |
| ISSN号 | 0513-4870 |
| 其他题名 | 基于片段的药物发现方法进展 |
| 文献子类 | Review |
| 英文摘要 | As an extension of the structure-based drug discovery, fragment-based drug discovery is matured increasingly, and plays an important role in drug development. Fragments in a small library, with lower molecular mass and high "ligand efficiency", are detected by SPR, MS, NMR, X-ray crystallography technologies and other biophysical methods. Then they are considered as starting points for chemical optimization with the guidance of structural biology methods to get good "drug-like" lead and candidate compounds. In this article, we reviewed the current progress of fragment-based drug discovery and detailed a number of examples to illustrate the novel strategies. |
| 资助项目 | 国家自然科学基金资助项目[00000000] ; 国家重大新药创制项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4724083 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267798]  |
| 专题 | 药物化学研究室 药物发现与设计中心 分析化学研究室 |
| 作者单位 | 1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai 201203, China.; 2.Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Ren Jing,Li Jian,Shi Feng,et al. Progress in the fragment-based drug discovery[J]. Acta Pharmaceutica Sinica,2013,48(1):14-24. |
| APA | Ren Jing.,Li Jian.,Shi Feng.,Wang Xin.,He Jianhua.,...&Shen Jingkang.(2013).Progress in the fragment-based drug discovery.Acta Pharmaceutica Sinica,48(1),14-24. |
| MLA | Ren Jing,et al."Progress in the fragment-based drug discovery".Acta Pharmaceutica Sinica 48.1(2013):14-24. |
入库方式： OAI收割
来源：上海药物研究所
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