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Advances in the structure-activity relationship study of natural flavonoids and its derivatives
文献类型：期刊论文
| 作者 | ZHONG Jianqing2; LI Bo1; JIA Qi2; LI Yiming2; ZHU Weiliang1 ; CHEN Kaixian2
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| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2011 |
| 卷号 | 46期号:6页码:622-630 |
| 关键词 | flavonoids derivatives structure-activity relationship |
| ISSN号 | 0513-4870 |
| 其他题名 | 天然黄酮类化合物及其衍生物的构效关系研究进展 |
| 文献子类 | Review |
| 英文摘要 | Flavonoids are a large class of compounds widely distributed in nature.Many pharmacological activities of flavonoids have been reported such as anti-cancer,antioxidant,anti-inflammatory,hepatoprotective,antithrombotic,vasodilator,antiviral,antibacterial,antiallergic,and so on.In recent years,domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities.As part of the mechanisms are not clear,we need to strengthen in-depth research in the SAR (structure-activity relationship)study for targeted and efficient structure optimization.This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives,which can serve as a reference for synthesizing new flavonoid derivatives. |
| 资助项目 | 国家重大新药创制科技重大专项资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4212530 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267883]  |
| 专题 | 药物发现与设计中心 |
| 作者单位 | 1.Drug Design and Discovery Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.College of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | ZHONG Jianqing,LI Bo,JIA Qi,et al. Advances in the structure-activity relationship study of natural flavonoids and its derivatives[J]. Acta Pharmaceutica Sinica,2011,46(6):622-630. |
| APA | ZHONG Jianqing,LI Bo,JIA Qi,LI Yiming,ZHU Weiliang,&CHEN Kaixian.(2011).Advances in the structure-activity relationship study of natural flavonoids and its derivatives.Acta Pharmaceutica Sinica,46(6),622-630. |
| MLA | ZHONG Jianqing,et al."Advances in the structure-activity relationship study of natural flavonoids and its derivatives".Acta Pharmaceutica Sinica 46.6(2011):622-630. |
入库方式： OAI收割
来源：上海药物研究所
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