DGAT:a new target for prevention and treatment of obesity and diabetes
文献类型：期刊论文
| 作者 | YAN Gui-rui; ZHANG Xiao-dong; ZHU Wei-liang ; WANG He-yao
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2010 |
| 卷号 | 22期号:2页码:173-178 |
| 关键词 | DGAT DGAT obesity fatty liver diabetes target |
| ISSN号 | 1004-0374 |
| 其他题名 | 潜在的防治肥胖及糖尿病靶标DGAT |
| 文献子类 | Review |
| 英文摘要 | Acly CoA:diacylglycerol acyltransferase(DGAT)is a key enzyme that catalyzes the final reaction of triacylgycerol(TG)synthesis.DGAT has two subtypes including DGAT1 and DGAT2.DGAT1 deficiency increased the sensitivity of tested mice to both insulin and leptin,and protected them against diet-induced obesity.Reducing DGAT2's expression in liver caused a marked reduction in hepatic TG content and improved hepatic steatosis of obese mice.DGAT inhibitors ameliorated hyperlipoidemia and fatty liver in vivo.Therefore,DGATs have been viewed as potential therapeutic targets for prevention and treatment of obesity and diabetes.The functions and inhibitors of DGAT are discussed in this review. |
| 资助项目 | 国家高技术研究发展计划("863"计划)[00000000] ; 中国科学院知识创新工程重要方向项目[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3860084 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267957]  |
| 专题 | 药物发现与设计中心 药理学第三研究室 |
| 作者单位 | Shanghai Institute of Materia Media,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | YAN Gui-rui,ZHANG Xiao-dong,ZHU Wei-liang,et al. DGAT:a new target for prevention and treatment of obesity and diabetes[J]. Chinese Bulletin of Life Sciences,2010,22(2):173-178. |
| APA | YAN Gui-rui,ZHANG Xiao-dong,ZHU Wei-liang,&WANG He-yao.(2010).DGAT:a new target for prevention and treatment of obesity and diabetes.Chinese Bulletin of Life Sciences,22(2),173-178. |
| MLA | YAN Gui-rui,et al."DGAT:a new target for prevention and treatment of obesity and diabetes".Chinese Bulletin of Life Sciences 22.2(2010):173-178. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。