Computational systems biology: theory, method and applications in drug discovery
文献类型：期刊论文
| 作者 | Diao Yanyan1; Cai Chaoqian2; Jiang Hualiang3 ; Li Honglin1
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2010 |
| 卷号 | 22期号:10页码:1035-1042 |
| 关键词 | computational systems biology biological models modeling methods |
| ISSN号 | 1004-0374 |
| 其他题名 | 计算系统生物学:理论,方法及在药物研发中的应用 |
| 文献子类 | Review |
| 英文摘要 | Computational systems biology is a multi-disciplinary field which aims at simulating the interactions of complex biological systems by integrating large quantities of biological data. In this process,it is essential to develop appropriate mathematical methods and simulation tools, which is also a main task of computational systems biology. The modeling of biological networks is of great value for further understanding the intrinsic properties of biological systems. Additionally, biological models have drawn increasing attention from pharma-ceutical companies and research institutions for their application in target identification, toxicity assessment and so on. This review provides a brief summary of the available biological networks and modeling methods, elucidates their applications, and points out further challenges remaining in computational systems biology |
| 资助项目 | 国家重点基础研究发展计划"(973"项目)[00000000] ; 国家自然科学基金项目[00000000] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4050123 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267959]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Jiang Hualiang |
| 作者单位 | 1.School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.; 2.School of Informa-tion Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.; 3.Drug Discov-ery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Diao Yanyan,Cai Chaoqian,Jiang Hualiang,et al. Computational systems biology: theory, method and applications in drug discovery[J]. Chinese Bulletin of Life Sciences,2010,22(10):1035-1042. |
| APA | Diao Yanyan,Cai Chaoqian,Jiang Hualiang,&Li Honglin.(2010).Computational systems biology: theory, method and applications in drug discovery.Chinese Bulletin of Life Sciences,22(10),1035-1042. |
| MLA | Diao Yanyan,et al."Computational systems biology: theory, method and applications in drug discovery".Chinese Bulletin of Life Sciences 22.10(2010):1035-1042. |
入库方式： OAI收割
来源：上海药物研究所
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