Molecular dynamics simulations studies on the structure-function relationship of protein targets related to Alzheimer's disease
文献类型：期刊论文
| 作者 | XU Ye-Chun ; JIANG Hua-Liang
|
| 刊名 | Journal of the Graduate School of the Academy of Sciences
 |
| 出版日期 | 2009 |
| 卷号 | 26期号:2页码:280-287 |
| 关键词 | Alzheimer's disease, molecular dynamics simulation, beta-amyloid peptide, acetylcholinesterase/huperzine A, nicotinic acetylcholine receptor |
| ISSN号 | 1002-1175 |
| 其他题名 | 老年痴呆相关蛋白靶标结构与功能关系的分子动力学模拟 |
| 文献子类 | Article |
| 英文摘要 | In the present thesis, the conformational changes of beta-amyloid peptide, the dynamic binding and unbinding processes of huperzine A to acetylcholinesterase, and the conformational movement associated with the open or close gating mechanism of nicotinic acetylcholine receptor have been investigated using conventional and/or steered molecular dynamics simulations, gaining new and useful insights for the pathogenetic mechanism of Alzheimer' s disease (AD), and providing new clues for discovering new anti-AD drugs. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3534371 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267986]  |
| 专题 | 药物发现与设计中心 |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | XU Ye-Chun,JIANG Hua-Liang. Molecular dynamics simulations studies on the structure-function relationship of protein targets related to Alzheimer's disease[J]. Journal of the Graduate School of the Academy of Sciences,2009,26(2):280-287. |
| APA | XU Ye-Chun,&JIANG Hua-Liang.(2009).Molecular dynamics simulations studies on the structure-function relationship of protein targets related to Alzheimer's disease.Journal of the Graduate School of the Academy of Sciences,26(2),280-287. |
| MLA | XU Ye-Chun,et al."Molecular dynamics simulations studies on the structure-function relationship of protein targets related to Alzheimer's disease".Journal of the Graduate School of the Academy of Sciences 26.2(2009):280-287. |
入库方式： OAI收割
来源：上海药物研究所
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