Research on HCPT Binding Peptides
文献类型：期刊论文
| 作者 | Zhu Wei2; Zhang Lianfen1; Lei Jianyong2; Gu Jiande3 ; Jin Jian2
|
| 刊名 | Biotechnology Bulletin
 |
| 出版日期 | 2009 |
| 期号 | 1页码:126 |
| 关键词 | 10-Hydroxyl camptothecine（HCPT） Binding peptide Phage display Molecular dynamics Dock |
| ISSN号 | 1002-5464 |
| 其他题名 | 羟喜树碱结合肽的研究 |
| 文献子类 | Article |
| 英文摘要 | Biotin-HCPT compound was synthesized by means of esterification-dehydration,purified with Resourse15 reversed-phase column and conformed by LC-MS. The anti-cancer activity of Biotin-HCPT was analyzed by SRB method. Fourteen HCPT binding peptides were identified by phage display. Structure models of HCPT binding peptides were built and then optimized by molecular dynamics. The binding effect between HCPT binding peptides and HCPT was verified and analyzed by docking. |
| 资助项目 | 江苏省卫生厅科研资金资助课题(H200625)[00000000] |
| WOS研究方向 | Plant Sciences (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3492865 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268019]  |
| 专题 | 药物发现与设计中心 |
| 作者单位 | 1.Laboratory of Molecular Pharmacology, School of Medicine and Pharmaceutics, Wuxi, Jiangsu 214122, China.; 2.The Key Laboratory of Industry Biotechnology, Ministry of Education, Jiangnan University, Wuxi, Jiangsu 214122, China.; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Zhu Wei,Zhang Lianfen,Lei Jianyong,et al. Research on HCPT Binding Peptides[J]. Biotechnology Bulletin,2009(1):126. |
| APA | Zhu Wei,Zhang Lianfen,Lei Jianyong,Gu Jiande,&Jin Jian.(2009).Research on HCPT Binding Peptides.Biotechnology Bulletin(1),126. |
| MLA | Zhu Wei,et al."Research on HCPT Binding Peptides".Biotechnology Bulletin .1(2009):126. |
入库方式： OAI收割
来源：上海药物研究所
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