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Advances in the study of berberine and its derivatives
文献类型：期刊论文
| 作者 | Li Bo1; Zhu Weiliang2 ; Chen Kaixian1
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:8页码:773-787 |
| 关键词 | natural product berberine derivatives structure-activity relationship drug design |
| ISSN号 | 0513-4870 |
| 其他题名 | 小檗碱及其衍生物的研究进展 |
| 文献子类 | Article |
| 英文摘要 | Berberine is a isoquinoline alkaloid extracted from Chinese herbs such as Coptidis rhizome.In the past decade,there are more than 2 000 published papers studying the clinical application,pharmacodynamic mechanism and structure-activity relationship(SAR)of berberine and its derivatives,for treating tumor,diabetes,cardiavascellum disease,hyperlipemia,inflammation,bacterium and virus infection,cerebral ischemia trauma,mental disease,Alzheimer disease,osteoporosis,and so on.These results demonstrate that berberine has wide physiologic function and has great potential for structural modification as new drug lead.However,there is no systematic review about the study of berberine and its derivatives up to now.This paper is a systematic review of the research advances of berberine and its derevatives in clinical application,pharmacodynamic mechanisms,molecular pharmacology,absorption and metabolism,and SAR studies.The current review would provide some useful information for further study on structural modification of berberine for discovering new drug leads based on its pharmacodynamic mechanisms. |
| 资助项目 | 国家重点基础研究计划(973计划)资助项目(2004CB518901)[00000000] ; 国家高技术研究发展计划(863计划)资助项目(2006AA02Z336)[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3363576 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268096]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Zhu Weiliang |
| 作者单位 | 1.College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; 2.Drug Design and Discovery Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Li Bo,Zhu Weiliang,Chen Kaixian. Advances in the study of berberine and its derivatives[J]. Acta Pharmaceutica Sinica,2008,43(8):773-787. |
| APA | Li Bo,Zhu Weiliang,&Chen Kaixian.(2008).Advances in the study of berberine and its derivatives.Acta Pharmaceutica Sinica,43(8),773-787. |
| MLA | Li Bo,et al."Advances in the study of berberine and its derivatives".Acta Pharmaceutica Sinica 43.8(2008):773-787. |
入库方式： OAI收割
来源：上海药物研究所
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