Investigation of quantitive control of residual petroleum ether in pharmaceuticals by gas capillary chromatography
文献类型：期刊论文
| 作者 | LI Ping; CHI Yinghong; CHEN Dongying
|
| 刊名 | Chinese Journal of Pharmaceutical Analysis
 |
| 出版日期 | 2008 |
| 卷号 | 28期号:3页码:427-430 |
| 关键词 | petroleum ether residual quantity gas chromatography （ GC ） method investigation |
| ISSN号 | 0254-1793 |
| 其他题名 | 药物中石油醚残留量的气相色谱检测方法学探讨 |
| 文献子类 | Article |
| 英文摘要 | Objective：A quantitative determination of residual petroleum ether in pharmaceuticals by gas chroma- tography（ GC ）was explored. Method：Using several batches of petroleum ether（60-90℃）obtained from market as samples, the separation was optimized to analyze the peak distributions of petroleum ether （ 60 - 90℃） combined with other residual solvents such as methanol, ethanol, dichloromethane, ethyl acetate, tetrahydrofuran and 1,4 -dioxane contained in a new drug candidate named as nifeviroc. Both calibration methods of peak area response based on one - component or multi - component （ S/N 〉 10 ） for petroleum ether （ 60 - 90℃） control in pharmaceutical were investigated. Results： It was found the quantitative determination for petroleum ether （ 60 - 90℃） based on multi - component calibration method had a good linear relationship and showed better rational control purpose. Sat- isfactory recoveries for all investigated residual solvents including petroleum ether（60 -90℃）were obtained. Conclusion：The proposed quantitative determination of petroleum ether（60 -90℃）can reduce the differences among different manufactures or different batches, thus then has a good quality control for pharmaceuticals concerned. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3317746 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268102]  |
| 专题 | 成果转移转化处 |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LI Ping,CHI Yinghong,CHEN Dongying. Investigation of quantitive control of residual petroleum ether in pharmaceuticals by gas capillary chromatography[J]. Chinese Journal of Pharmaceutical Analysis,2008,28(3):427-430. |
| APA | LI Ping,CHI Yinghong,&CHEN Dongying.(2008).Investigation of quantitive control of residual petroleum ether in pharmaceuticals by gas capillary chromatography.Chinese Journal of Pharmaceutical Analysis,28(3),427-430. |
| MLA | LI Ping,et al."Investigation of quantitive control of residual petroleum ether in pharmaceuticals by gas capillary chromatography".Chinese Journal of Pharmaceutical Analysis 28.3(2008):427-430. |
入库方式： OAI收割
来源：上海药物研究所
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