Determination of glaucocalyxin A by HPLC and its protein binding rate in plasma of rat
文献类型：期刊论文
| 作者 | CAO Luye1; CHEN Zijun3; LI Yunsen2; LI Yikui3 |
| 刊名 | Chinese Traditional and Herbal Drugs
 |
| 出版日期 | 2007 |
| 卷号 | 38期号:5页码:693-695 |
| 关键词 | glaucocalyxin A protein binding rate HPLC |
| ISSN号 | 0253-2670 |
| 其他题名 | 高效液相色谱法研究蓝萼甲素与大鼠血浆蛋白的结合率 |
| 文献子类 | Article |
| 英文摘要 | Objective To study the protein binding rate of glaucocalyxin A in plasma of rat. Methods The plasma balance dialysis was used. An HPLC for the quantitative determination of glaucocalyxin A was presented and used to calculate the protein binding rate in plasma of rat. Results There were protein binding rate results of 74.46%, 77.87%, and 75.29% at three various concentrations 20, 10, and 1 mug/ mL of glaucocalyxin A in plasma of rat. Conclusion The HPLC method used to determine glaucocalyxin A is simple, rapid, and sensitive with good specificity, precision and accuracy, and glaucocalyxin A has medium capacities in protein binding rate in plasma of rat. |
| 资助项目 | 国家科技部863计划创新药物和中药现代化新药博士基金资助课题[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2872915 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268135]  |
| 专题 | 信息中心 药理学第二研究室 药理学第一研究室 |
| 作者单位 | 1.Guangdong Vocational College of Chemical Engineering and Pharmaceutics, Guangzhou, Guangdong 510520, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 3.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | CAO Luye,CHEN Zijun,LI Yunsen,et al. Determination of glaucocalyxin A by HPLC and its protein binding rate in plasma of rat[J]. Chinese Traditional and Herbal Drugs,2007,38(5):693-695. |
| APA | CAO Luye,CHEN Zijun,LI Yunsen,&LI Yikui.(2007).Determination of glaucocalyxin A by HPLC and its protein binding rate in plasma of rat.Chinese Traditional and Herbal Drugs,38(5),693-695. |
| MLA | CAO Luye,et al."Determination of glaucocalyxin A by HPLC and its protein binding rate in plasma of rat".Chinese Traditional and Herbal Drugs 38.5(2007):693-695. |
入库方式： OAI收割
来源：上海药物研究所
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