Purification, structure elucidation and antitumor activity of minor antibiotics M3 and M4 in the fermentation broth of Streptomyces hygrosopicus NND-52
文献类型：期刊论文
| 作者 | Yang Hongling2; Huang Weiyi2; Yang Yiping1
|
| 刊名 | Chinese Journal of Antibiotics
 |
| 出版日期 | 2006 |
| 卷号 | 31期号:5页码:274-277 |
| 关键词 | Isolation Structure Herbimycin C Dihydroherbimycin A Antitumor |
| ISSN号 | 1001-8689 |
| 其他题名 | 除莠霉素A结构类似物M3、M4的分离鉴定及对肿瘤细胞的活性 |
| 文献子类 | Article |
| 英文摘要 | Antibiotic M3 and M4 were isolated from the cultured broth of Streptomyces hygroscopicus NND-52 by ethyl acetate extraction, silica gel column chromatography and preparative high performance liquid chromatogra-phy. Basic physical and chemical characteristics and spectra data showed antibiotic M3 and M4 are herbimycin C and dihydroherbimycin A, respectively. The effects of herbimycin A, herbimycin C and dihydroherbimycin A on proliferation of Vero and B16-F10 cells were investigated by MTT assay. Results showed that their antitumor activities were as follows: herbimycin Oherbimycin A>dihydroherbimycin A. Compared with herbimycin A, herbimycin C is a more potentially applicable antitumor antibiotic. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2568792 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268179]  |
| 专题 | 信息中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Science, Shanghai 201203, China. 2.College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China.; |
| 推荐引用方式 GB/T 7714 | Yang Hongling,Huang Weiyi,Yang Yiping. Purification, structure elucidation and antitumor activity of minor antibiotics M3 and M4 in the fermentation broth of Streptomyces hygrosopicus NND-52[J]. Chinese Journal of Antibiotics,2006,31(5):274-277. |
| APA | Yang Hongling,Huang Weiyi,&Yang Yiping.(2006).Purification, structure elucidation and antitumor activity of minor antibiotics M3 and M4 in the fermentation broth of Streptomyces hygrosopicus NND-52.Chinese Journal of Antibiotics,31(5),274-277. |
| MLA | Yang Hongling,et al."Purification, structure elucidation and antitumor activity of minor antibiotics M3 and M4 in the fermentation broth of Streptomyces hygrosopicus NND-52".Chinese Journal of Antibiotics 31.5(2006):274-277. |
入库方式： OAI收割
来源：上海药物研究所
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