Interaction of Alzheimer~s disease and brain ischemia
文献类型：期刊论文
| 作者 | LIU Jing; ZHU XingZu |
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2006 |
| 卷号 | 18期号:5页码:473-476 |
| 关键词 | Alzheimer＇s disease brain ischemia apolipoprotein E glial cells neuroinflammation |
| ISSN号 | 1004-0374 |
| 其他题名 | 阿尔采末病与脑缺血的相互作用 |
| 文献子类 | Review |
| 英文摘要 | Recent advances suggest that brain ischemia contribute to the pathogenesis of Alzheimer＇s disease （AD） and individual with severe cognitive decline and possibly underlying AD are at increased risk for ischemic events in the brain. The e4 allele of apolipoprotein E （ApoE） is a risk factor for both AD and poor outcome following brain ischemia and hemorrhage. The development of both AD neuropathology and ischemic lesions in the central nervous system are characterized by activation of glial cells and upregulation of inflammatory mediators. Anti-inflammatory approaches have proven to be beneficial in the prevention and treatment of AD and ischemic injuries in vivo. |
| 资助项目 | 国家自然科学基金[00000000] |
| WOS研究方向 | Neurosciences & Neurology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2547948 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268259]  |
| 专题 | 分析化学研究室 药物发现与设计中心 上海药物代谢研究中心 |
| 作者单位 | Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | LIU Jing,ZHU XingZu. Interaction of Alzheimer~s disease and brain ischemia[J]. Chinese Bulletin of Life Sciences,2006,18(5):473-476. |
| APA | LIU Jing,&ZHU XingZu.(2006).Interaction of Alzheimer~s disease and brain ischemia.Chinese Bulletin of Life Sciences,18(5),473-476. |
| MLA | LIU Jing,et al."Interaction of Alzheimer~s disease and brain ischemia".Chinese Bulletin of Life Sciences 18.5(2006):473-476. |
入库方式： OAI收割
来源：上海药物研究所
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