Effect of the Extract ZG from Gardenia on the Cell Adsorption of Herpes Simplex Virus Type I（HSV-1）
文献类型：期刊论文
| 作者 | GUO Shunshan2; WANG Xiukun2; ZHANG Yuanyuan1; GAO Yingjie2; HUANG Yang2; ZHAO Ye2; GONG Wenfeng2; CUI Xiaolan2 |
| 刊名 | Chinese Journal of Virology
 |
| 出版日期 | 2006 |
| 卷号 | 22期号:3页码:198-202 |
| 关键词 | extract ZG from Gardenia herpes simplex virus type 1 （HSV-1） virus attachment protein（VAP） cooling charged-coupled device （cCCD） fluorescein isothiocyanate （FITC） hcparin sodium |
| ISSN号 | 1000-8721 |
| 其他题名 | 栀子提取物ZG对单纯疱疹病毒1型细胞吸附的影响 |
| 文献子类 | Article |
| 英文摘要 | Negative-staining technique was used to investigate whether the extract ZG from Gardenia could change or destroy the virus envelope protein structure to weaken HSV-1 virulence. After treated with extract ZG from Gardenia, the HSV-I particles and the virus attachment proteins（VAPs） on virus surface were observed under electron microscope. Fluorescein isothiocyanate （FITC） as HSV-1 fluorescent probe and heparin sodium as the control samplc, we adopted the cooling charged-coupled device （cCCD） and Aquacomos analysis software to study thc effect of extract ZG from Gardenia on the cell adsorption quantity of HSV-1 in different methods. The results showed that extract ZG from Gardenia didn＇t directly destroy VAPs of HSV-1 . Both the group adding heparin sodium first and the group adding heparin sodium and virus simultaneously could prevent the viral bind ing to Hep 2 cells. Adding extract ZG from Gardenia in different ways all could prevent the HSV-1 binding to the Hep-2 cell surface and reduce the virus adsorption quantity. |
| 资助项目 | 国家自然科学基金面上项目[00000000] |
| WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:2449173 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268262]  |
| 专题 | 药物发现与设计中心 |
| 作者单位 | 1.Chinese Institute of Materia Medica, Shanghai Institute for Biological Seiences, Chinese Academy of Sciences, Shanghai 201203, China. 2.Institute of Chinese Meteria Medina, China Academy of Traditional Chinese Medicine, Beijing 100700, China.; |
| 推荐引用方式 GB/T 7714 | GUO Shunshan,WANG Xiukun,ZHANG Yuanyuan,等. Effect of the Extract ZG from Gardenia on the Cell Adsorption of Herpes Simplex Virus Type I（HSV-1）[J]. Chinese Journal of Virology,2006,22(3):198-202. |
| APA | GUO Shunshan.,WANG Xiukun.,ZHANG Yuanyuan.,GAO Yingjie.,HUANG Yang.,...&CUI Xiaolan.(2006).Effect of the Extract ZG from Gardenia on the Cell Adsorption of Herpes Simplex Virus Type I（HSV-1）.Chinese Journal of Virology,22(3),198-202. |
| MLA | GUO Shunshan,et al."Effect of the Extract ZG from Gardenia on the Cell Adsorption of Herpes Simplex Virus Type I（HSV-1）".Chinese Journal of Virology 22.3(2006):198-202. |
入库方式： OAI收割
来源：上海药物研究所
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