Progress in the studies of the structure and function of mitochondria permeability transition pore
文献类型：期刊论文
| 作者 | Guo Hongxia; Tu Changying; Chen Jing ; Jiang Hualiang; Shen Xu
|
| 刊名 | Chinese Bulletin of Life Sciences
 |
| 出版日期 | 2005 |
| 卷号 | 17期号:1页码:49-54 |
| 关键词 | MPTP (mitochondria permeability transition pore) ANT (adenine nucleotide translocator) CypD (cyclophilin D) VDAC (voltage-dependent anion channel) CSA (Cyclosporin A) |
| ISSN号 | 1004-0374 |
| 其他题名 | 线粒体渗透性转变孔结构和功能的研究进展 |
| 文献子类 | Article |
| 英文摘要 | Abnormally high concentration of Ca2+ and oxide stress can stimulate the opening of the mitochondria permeability transition pore (MPTP) and cause the change of mitochondria shape and function. The factors released by mitochondria, such as cytochrome c and AIF (apoptosis-inducing factor) involve in the signaling pathway of caspases and induce cell apoptosis. This article describes the recent progress in the studies of the main components and two different models of the MPTP, the mechanism of the inhibition of CSA and Sf A to MPTP and the influence of ischemia /reperfusion and ischaemic preconditioning to the opening of MPTP. |
| 资助项目 | 国家自然科学基金项目[00000000] ; 国家"973"项目[00000000] |
| WOS研究方向 | Cell Biology (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:1874979 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268338]  |
| 专题 | 药物安全性评价中心 药物发现与设计中心 |
| 作者单位 | Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Guo Hongxia,Tu Changying,Chen Jing,et al. Progress in the studies of the structure and function of mitochondria permeability transition pore[J]. Chinese Bulletin of Life Sciences,2005,17(1):49-54. |
| APA | Guo Hongxia,Tu Changying,Chen Jing,Jiang Hualiang,&Shen Xu.(2005).Progress in the studies of the structure and function of mitochondria permeability transition pore.Chinese Bulletin of Life Sciences,17(1),49-54. |
| MLA | Guo Hongxia,et al."Progress in the studies of the structure and function of mitochondria permeability transition pore".Chinese Bulletin of Life Sciences 17.1(2005):49-54. |
入库方式： OAI收割
来源：上海药物研究所
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