Complicated intermolecular interactions formed between organofluorine and drug target
文献类型：期刊论文
| 作者 | WANG Gui-min1,2; ZHU Zheng-dan1,2; CHEN Zhao-qiang2; XU Zhi-jian2 ; ZHU Wei-liang1,2
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2018 |
| 卷号 | 53期号:5页码:701-708 |
| 关键词 | organofluorine weak intermolecular interaction hydrogen bond halogen bond C-F⋯pi interaction |
| ISSN号 | 0513-4870 |
| 其他题名 | 有机含氟药物与靶标蛋白质的复杂分子间相互作用 |
| 文献子类 | Review |
| 英文摘要 | Fluorinated compounds, which now make up 20%-25% of all marketed chemical drugs, are playing significant role and showing great potential in medicinal chemistry. Fluorine substitution is always utilized to change the physicochemical properties of the compounds to improve the ADME/T properties. In addition, fluorine substitution leads to improvement of the ligand binding affinity. With respect to molecular level, organofluorine can form various intermolecular interactions with the target proteins, e.g., hydrogen bond, halogen bond, C-F⋯pi interaction, polar interaction and so on. These interactions display unique properties or nature due to the specificity of fluorine atom, which are at the center of attention. This paper reviews the related research background, followed by the research progress of hydrogen bond, halogen bond, C-F⋯pi interaction, polar interaction and some other interactions involved organofluorine. |
| 资助项目 | 国家重点研发计划资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6248861 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269172]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | ZHU Wei-liang |
| 作者单位 | 1.University of Chinese Academy of Sciences, Beo＇ing 100049, China 2.CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; |
| 推荐引用方式 GB/T 7714 | WANG Gui-min,ZHU Zheng-dan,CHEN Zhao-qiang,et al. Complicated intermolecular interactions formed between organofluorine and drug target[J]. Acta Pharmaceutica Sinica,2018,53(5):701-708. |
| APA | WANG Gui-min,ZHU Zheng-dan,CHEN Zhao-qiang,XU Zhi-jian,&ZHU Wei-liang.(2018).Complicated intermolecular interactions formed between organofluorine and drug target.Acta Pharmaceutica Sinica,53(5),701-708. |
| MLA | WANG Gui-min,et al."Complicated intermolecular interactions formed between organofluorine and drug target".Acta Pharmaceutica Sinica 53.5(2018):701-708. |
入库方式： OAI收割
来源：上海药物研究所
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