Research progress in VEGFR-2 inhibitors
文献类型：期刊论文
| 作者 | Liu Peng; Zhou Yunfei; Zhang Yong; Wang Guimin; Chen Zhaoqiang; Li Bo; Xu Zhijian ; Zhu Weiliang
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2017 |
| 卷号 | 52期号:4页码:531-540 |
| 关键词 | VEGFR-2 VEGFR-2 inhibitors tumor selectivity |
| ISSN号 | 0513-4870 |
| 其他题名 | VEGFR-2抑制剂研究进展 |
| 文献子类 | Review |
| 英文摘要 | Vascular endothelial growth factor receptor (VEGFR-2), a member of the super family of protein tyrosine kinase receptors, plays a vital role in the regulation of tumor metastasis and angiogenesis. Several VEGFR-2 inhibitors have been marketed as antitumor drugs and a range of inhibitors are undergoing clinical or preclinical studies. According to the principle of multi-targeted pharmacolgy, in the field of tumor treatment, nonselective drugs targeting on more than one kinase to inhibit different cell pathways can be more effective than drugs specific for one kinase. Multi-target treatment does not mean abandonment of selectivity, but a precise selectivity for several kinases related to tumor, which is also a big challenge in the development of small molecular antitumor drugs. This paper reviews briefly the advances in research of the VEGFR-2 inhibitors and selectivity strategy in recent years. |
| 资助项目 | 上海市扬帆计划资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5955467 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/269211]  |
| 专题 | 药物发现与设计中心 |
| 通讯作者 | Zhu Weiliang |
| 作者单位 | ACS Key Laboratory of Receptor Research,Drug Discovery and Design Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Liu Peng,Zhou Yunfei,Zhang Yong,et al. Research progress in VEGFR-2 inhibitors[J]. Acta Pharmaceutica Sinica,2017,52(4):531-540. |
| APA | Liu Peng.,Zhou Yunfei.,Zhang Yong.,Wang Guimin.,Chen Zhaoqiang.,...&Zhu Weiliang.(2017).Research progress in VEGFR-2 inhibitors.Acta Pharmaceutica Sinica,52(4),531-540. |
| MLA | Liu Peng,et al."Research progress in VEGFR-2 inhibitors".Acta Pharmaceutica Sinica 52.4(2017):531-540. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。