SPECIFIC TARGETING OF MITOMYCIN-C TO TUMORS BY ANTIGASTRIC CANCER MONOCLONAL-ANTIBODY
文献类型：期刊论文
| 作者 | LI, S; ZHANG, XY; CHEN, XT; FAN, DM; ZHANG, SY; CHEN, LJ; SHU, YH; ZHANG, JL |
| 刊名 | CHINESE MEDICAL JOURNAL
 |
| 出版日期 | 1991-05 |
| 卷号 | 104期号:5页码:358-362 |
| ISSN号 | 0366-6999 |
| 文献子类 | Article |
| 英文摘要 | In the present study, an anti-gastric cancer monoclonal antibody, MGb2, was chosen to prepare antibody-mitomycin C (MMC) conjugate with dextran T-40 as intermediary. Twenty molecules of MMC were introduced into each molecule of antibody while the antigen-binding capacity of the antibody was kept well. The conjugate showed selective cytotoxicity upon human gastric cancer cell line SGC-7901. Radioimmunoimaging and biodistribution studies indicated that after conjugation with MMC via dextran T-40 as intermediary, the tumor localization capacity of the antibody was well retained. When tested in nude mice, inoculated with human gastric carcinoma SGC-7901 in bilateral subrenal capsules, intraperitoneal injection of the conjugate daily for 6 days at a dose of 1 mg/kg gave a tumor inhibitory rate of 68.67%, which was far better than that of free MMC or irrelevant conjugate. No synergetic effect was found in regard to the mixture of MGb2 with MMC. |
| WOS关键词 | CONJUGATE ; MOUSE |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:A1991FN30500002 |
| 出版者 | CHINESE MEDICAL ASSOCIATION |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275202]  |
| 专题 | 成果转移转化处 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | LI, S,ZHANG, XY,CHEN, XT,et al. SPECIFIC TARGETING OF MITOMYCIN-C TO TUMORS BY ANTIGASTRIC CANCER MONOCLONAL-ANTIBODY[J]. CHINESE MEDICAL JOURNAL,1991,104(5):358-362. |
| APA | LI, S.,ZHANG, XY.,CHEN, XT.,FAN, DM.,ZHANG, SY.,...&ZHANG, JL.(1991).SPECIFIC TARGETING OF MITOMYCIN-C TO TUMORS BY ANTIGASTRIC CANCER MONOCLONAL-ANTIBODY.CHINESE MEDICAL JOURNAL,104(5),358-362. |
| MLA | LI, S,et al."SPECIFIC TARGETING OF MITOMYCIN-C TO TUMORS BY ANTIGASTRIC CANCER MONOCLONAL-ANTIBODY".CHINESE MEDICAL JOURNAL 104.5(1991):358-362. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。