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Biotransformation of Gambogenic Acid by Chaetomium globosum CICC 2445

文献类型：期刊论文

作者Tao, Si-Jia2; Wang, Yang1,2; Zhang, Xing3; Guan, Shu-Hong2; Guo, De-An2
刊名NATURAL PRODUCT COMMUNICATIONS
出版日期2012-02
卷号7期号:2页码:197-198
关键词Biotransformation Gambogenic acid 16,17-Dihydroxygambogenic acid Chaetomium globosum CICC 2445
ISSN号1934-578X
文献子类Article
英文摘要Microbial transformation of gambogenic acid (1), a caged polyprenylated xanthone isolated from the resin of Garcinia hanburyi, was carried out with Chaetomium globosum CICC 2445, after screening forty-six strains of filamentous fungi. A new caged polyprenylated xanthone, 16,17-dihydroxygambogenic acid (2), was specifically obtained, as a result of hydroxylation at C-16, and C-17. Its structure was elucidated on the basis of spectroscopic methods. The cytotoxicity of compounds I and 2 against HeLa tumor cell line was evaluated, with both of them being modestly active.
WOS关键词GARCINIA-HANBURYI ; XANTHONES ; RESIN
资助项目National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09308-005] ; Chinese Academy of Sciences[KSCX2-YW-R-166] ; National Science Foundation of Shanghai, China[10ZR1436400]
WOS研究方向Pharmacology & Pharmacy ; Food Science & Technology
语种英语
WOS记录号WOS:000300817600019
出版者NATURAL PRODUCTS INC
源URL[http://119.78.100.183/handle/2S10ELR8/278187]  
专题成果转移转化处
上海中药现代化研究中心
通讯作者Guan, Shu-Hong
作者单位1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;
3.Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Mat Med, Tianjin 300193, Peoples R China
推荐引用方式
GB/T 7714		 Tao, Si-Jia,Wang, Yang,Zhang, Xing,et al. Biotransformation of Gambogenic Acid by Chaetomium globosum CICC 2445[J]. NATURAL PRODUCT COMMUNICATIONS,2012,7(2):197-198.
APA Tao, Si-Jia,Wang, Yang,Zhang, Xing,Guan, Shu-Hong,&Guo, De-An.(2012).Biotransformation of Gambogenic Acid by Chaetomium globosum CICC 2445.NATURAL PRODUCT COMMUNICATIONS,7(2),197-198.
MLA Tao, Si-Jia,et al."Biotransformation of Gambogenic Acid by Chaetomium globosum CICC 2445".NATURAL PRODUCT COMMUNICATIONS 7.2(2012):197-198.

入库方式： OAI收割

来源：上海药物研究所

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