A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei
文献类型：期刊论文
| 作者 | Liang, Yong-hong1; Wang, Wei5; Yu, Si-wang1; Ye, Min1; He, Xiang-hui1; Gong, Ning-bo3,4; Lu, Yang3,4; Khan, Ikhlas A.5; Guo, De-an1,2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2010-12 |
| 卷号 | 81期号:8页码:988-991 |
| 关键词 | Drynaria fortunei Polypodiaceae Triterpenoid Chiratane Cytotoxic activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2010.06.013 |
| 文献子类 | Article |
| 英文摘要 | Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20 beta-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC50 of 2.92 mu M, 1.08 mu M and 2.45 mu M, respectively. (C) 2010 Elsevier B.V. All rights reserved. |
| WOS关键词 | DRYOPTERIS-CRASSIRHIZOMA ; SWERTIA-CHIRATA ; NMR-SPECTRA ; HOPANE ; CONSTITUENTS ; LEAVES |
| 资助项目 | Program Changjiang Scholar and Innovative Team in University[985-2-063-112] ; Peking University Health Science Center[985-2-119-121] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000285281800005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278705]  |
| 专题 | 上海中药现代化研究中心 期刊编辑部 |
| 通讯作者 | Ye, Min |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China; 2.CAS, Shanghai Res Ctr Modernizat TCM, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Peking Union Med Coll, Beijing 100021, Peoples R China; 4.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China; 5.Univ Mississippi, Sino US TCM Res Ctr, Natl Ctr Nat Prod Res, Inst Pharmaceut Sci, University, MS 38677 USA; |
| 推荐引用方式 GB/T 7714 | Liang, Yong-hong,Wang, Wei,Yu, Si-wang,et al. A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei[J]. FITOTERAPIA,2010,81(8):988-991. |
| APA | Liang, Yong-hong.,Wang, Wei.,Yu, Si-wang.,Ye, Min.,He, Xiang-hui.,...&Guo, De-an.(2010).A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei.FITOTERAPIA,81(8),988-991. |
| MLA | Liang, Yong-hong,et al."A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei".FITOTERAPIA 81.8(2010):988-991. |
入库方式： OAI收割
来源：上海药物研究所
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