Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways
文献类型：期刊论文
| 作者 | Liu, Qiong; Zhang, Yu; Lin, Zhonghui; Shen, Hong; Chen, Lili ; Hu, Lihong; Jiang, Hualiang; Shen, Xu
|
| 刊名 | JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
 |
| 出版日期 | 2010-06 |
| 卷号 | 120期号:4-5页码:155-163 |
| 关键词 | Danshen 15,16-Dihydrotanshinone I Glucocorticoid receptor Mineralocorticoid receptor AMP-activated kinase |
| ISSN号 | 0960-0760 |
| DOI | 10.1016/j.jsbmb.2010.03.090 |
| 文献子类 | Article |
| 英文摘要 | Hypertension is a common complication of type 2 diabetes mellitus (T2DM), and is the main cause for T2DM-associated mortality. Although the stringent control of blood pressure is known to be beneficial in reducing the cardiovascular mortality of T2DM patients, drugs with both anti-hypertensive and anti-hyperglycemic effects are seldom reported. The traditional Chinese medicine danshen has long been used for lowering both blood pressure and blood glucose in T2DM patients, shedding lights on the development of such medication. However, the molecular mechanism and active component remain unclear. Here, we report that the lipophilic component, 15,16-dihydrotanshinone I (DHTH) from danshen potently antagonized both mineralocorticoid and glucocorticoid receptors, and efficiently inhibited the expression of their target genes like Na+/K+ ATPase, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK). In addition, DHTH increased AMPK alpha phosphorylation and regulated its downstream pathways, including increasing acetyl-CoA carboxylase (ACC) phosphorylation, inhibiting transducer of regulated CREB activity 2 (TORC2) translocation and promoting glucose uptake. Such discovered multi-target effects of DHTH are expected to have provided additional understandings on the molecular basis of the therapeutic effects of danshen against the metabolic syndrome. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | ANGIOTENSIN-CONVERTING-ENZYME ; GLUT4 TRANSLOCATION ; KINASE ; ALDOSTERONE ; HYPERTENSION ; INHIBITION ; ACTIVATION ; TRANSPORT ; DISEASE ; RISK |
| 资助项目 | State Key Program of Basic Research of China[2010CB912501] ; State Key Program of Basic Research of China[2007AA02Z147] ; National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[30890044] ; National Natural Science Foundation of China[20721003] ; Key New Drug Creation and Manufacturing Program[2009ZX09301-001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000279566400002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278891]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第三研究室 |
| 通讯作者 | Hu, Lihong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qiong,Zhang, Yu,Lin, Zhonghui,et al. Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways[J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,2010,120(4-5):155-163. |
| APA | Liu, Qiong.,Zhang, Yu.,Lin, Zhonghui.,Shen, Hong.,Chen, Lili.,...&Shen, Xu.(2010).Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,120(4-5),155-163. |
| MLA | Liu, Qiong,et al."Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways".JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 120.4-5(2010):155-163. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。