L-Stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease
文献类型：期刊论文
| 作者 | Mo, Jiao; Zhang, Hai; Yu, Lei-Ping; Sun, Pei-Hua; Jin, Guo-Zhang ; Zhen, Xuechu
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| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2010-06 |
| 卷号 | 31期号:6页码:926-936 |
| 关键词 | L-Stepholidine Parkinson's disease Dyskinesia 5-HT1A receptor Partial agonist |
| ISSN号 | 0197-4580 |
| DOI | 10.1016/j.neurobiolaging.2008.06.017 |
| 文献子类 | Article |
| 英文摘要 | L-3,4-Dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) remains a challenge in Parkinson's disease (PD) drug therapy. In the present study, we examined the effect of L-stepholidine (L-SPD), a known dual dopamine receptor agent, on LID in 6-hydroxydopamine (6-OHDA)-lesioned PD rat model. Daily administration of L-DOPA to PD rats for 22 days induced steady expression of LID, co-administration of L-SPD with L-DOPA significantly ameliorated LID without compromising the therapeutic potency of L-DOPA, indicating that L-SPD attenuated LID development. L-SPD alone elicited stable contralateral rotational behavior without inducing significant dyskinesia. Acute administration of L-SPD to rats with established LID produced significant relief of dyskinesia; this effect was mimicked by ID, receptor antagonist haloperidol, but blunted by 5-HT1A receptor antagonist WAY 100635. Furthermore, the mRNA level of 5-HT1A decreased significantly on 6-OHDA-lesioned striata, whereas chronic L-SPD treatment restored 5-HT1A receptor mRNA level on the lesioned striata. The present data demonstrated that L-SPD elicited antidyskinesia effects via both dopamine (D-2 receptor antagonistic activity) and nondopamine (5-HT1A agonistic activity) mechanisms. (C) 2008 Elsevier Inc. All rights reserved. |
| WOS关键词 | LEVODOPA-INDUCED DYSKINESIA ; RECEPTOR ANTAGONIST ; PHARMACOLOGICAL VALIDATION ; CLINICAL-IMPLICATIONS ; ROTATIONAL BEHAVIOR ; LESIONED RATS ; MESSENGER-RNA ; ANIMAL-MODELS ; D3 RECEPTOR ; EXPRESSION |
| 资助项目 | Ministry of Science and Technology of China[2007AA02z163] ; Ministry of Science and Technology of China[2007CB935804] ; Shanghai Pujiang Project[07PJ14104] ; Natural Science Foundation of China[30572168] |
| WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000277246400005 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278892]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhen, Xuechu |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Dept Neuropharmacol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mo, Jiao,Zhang, Hai,Yu, Lei-Ping,et al. L-Stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease[J]. NEUROBIOLOGY OF AGING,2010,31(6):926-936. |
| APA | Mo, Jiao,Zhang, Hai,Yu, Lei-Ping,Sun, Pei-Hua,Jin, Guo-Zhang,&Zhen, Xuechu.(2010).L-Stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.NEUROBIOLOGY OF AGING,31(6),926-936. |
| MLA | Mo, Jiao,et al."L-Stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease".NEUROBIOLOGY OF AGING 31.6(2010):926-936. |
入库方式： OAI收割
来源：上海药物研究所
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