Design and synthesis of biotin-tagged photoaffinity probes of jasmonates
文献类型：期刊论文
| 作者 | Gu, Min2,3,4 ; Yan, Jianbin1; Bai, Zhiyan1; Chen, Yue-Ting4; Lu, Wei2,3; Tang, Jie2,3; Duan, Liusheng1; Xie, Daoxin1; Nan, Fa-Jun4
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
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| 出版日期 | 2010-05-01 |
| 卷号 | 18期号:9页码:3012-3019 |
| 关键词 | Jasmonate Coronatine Photoaffinity probes Synthesis |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2010.03.059 |
| 文献子类 | Article |
| 英文摘要 | Jasmonates (JAs) are a class of oxylipin compounds that play diverse roles in plant defense and development. The F-box protein coronatine insensitive1 (COI1) plays a crucial role in the JA signaling pathway. To determine whether COI1 binds directly to jasmonates, three biotin-tagged photoaffinity probes for JAs, a jasmonic acid photoaffinity probe (PAJA), a JAIle photoaffinity probe (PAJAIle), and a coronatine photoaffinity probe (PACOR), were designed and synthesized based on analysis of JA structure-activity relationships and molecular modeling of the interaction between COI1 and JAs. Among them, PACOR exhibited the most significant biological activity in inhibiting root growth, promoting accumulation of JA-responsive proteins, and triggering COI1-JAZ1 interaction in Arabidopsis seedlings. PACOR is an effective tool for elucidating the interaction between COI1 and JA. (c) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BOX PROTEIN TIR1 ; AUXIN RECEPTOR ; ARABIDOPSIS ; DEFENSE ; GROWTH ; GENE ; OCTADECANOIDS ; CORONATINE ; ACID ; BIOSYNTHESIS |
| 资助项目 | National Natural Science Foundation of China[30630044] ; National Natural Science Foundation of China[30725049] ; National Natural Science Foundation of China[30800593] ; National Natural Science Foundation of China[90717103] ; National Natural Science Foundation of China[90813037] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000277083400003 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278904]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xie, Daoxin |
| 作者单位 | 1.Tsinghua Univ, Sch Life Sci, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China; 2.E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China; 3.E China Normal Univ, Inst Med Chem, Shanghai 200062, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening,State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Min,Yan, Jianbin,Bai, Zhiyan,et al. Design and synthesis of biotin-tagged photoaffinity probes of jasmonates[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(9):3012-3019. |
| APA | Gu, Min.,Yan, Jianbin.,Bai, Zhiyan.,Chen, Yue-Ting.,Lu, Wei.,...&Nan, Fa-Jun.(2010).Design and synthesis of biotin-tagged photoaffinity probes of jasmonates.BIOORGANIC & MEDICINAL CHEMISTRY,18(9),3012-3019. |
| MLA | Gu, Min,et al."Design and synthesis of biotin-tagged photoaffinity probes of jasmonates".BIOORGANIC & MEDICINAL CHEMISTRY 18.9(2010):3012-3019. |
入库方式： OAI收割
来源：上海药物研究所
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