Dihydroxylation of 9,10-Dihydrobenzo[h]coumarins and Synthesis of Their Ester Derivatives
文献类型：期刊论文
| 作者 | Wang Jie1; Xia Peng1; Wang Yang1,2 |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2010-05 |
| 卷号 | 30期号:5页码:726-730 |
| 关键词 | 9,10-dihydrobenzo[h]coumarin dihydroxylation overoxidation camphanoyl ester |
| ISSN号 | 0253-2786 |
| 文献子类 | Article |
| 英文摘要 | The asymmetric dihydroxylation of 9,10-dihydrobenzo[h]coumarins (1a, 1b) provided not only enantiomerically enriched cis-7,8-diols (2a, 2b) but also 7-keto-8-hydroxy compounds 3a, 3b which were obtained in moderate yields (52% and 45%, respectively) by the overoxidation of the corresponding diols. The influence of the amount of oxidant and the reaction temperature on the distribution of products were discussed and the ee values of the diols 2a, 2b were deduced approximately from the diasteromeric ratios of their corresponding camphanoyl esters (4a, 4b) by (1)H NMR spectra. The structures of overoxidation product 3b and its camphanoyl ester 5b were determined by X-ray diffraction analysis. |
| WOS关键词 | CATALYZED ASYMMETRIC DIHYDROXYLATION ; OLEFINS |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| WOS记录号 | WOS:000278561000015 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278907]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Wang Jie |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Jie,Xia Peng,Wang Yang. Dihydroxylation of 9,10-Dihydrobenzo[h]coumarins and Synthesis of Their Ester Derivatives[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2010,30(5):726-730. |
| APA | Wang Jie,Xia Peng,&Wang Yang.(2010).Dihydroxylation of 9,10-Dihydrobenzo[h]coumarins and Synthesis of Their Ester Derivatives.CHINESE JOURNAL OF ORGANIC CHEMISTRY,30(5),726-730. |
| MLA | Wang Jie,et al."Dihydroxylation of 9,10-Dihydrobenzo[h]coumarins and Synthesis of Their Ester Derivatives".CHINESE JOURNAL OF ORGANIC CHEMISTRY 30.5(2010):726-730. |
入库方式： OAI收割
来源：上海药物研究所
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