Most Efficient Routes for the Synthesis of alpha,beta-Diamino Acid-Derived Compounds
文献类型：期刊论文
| 作者 | Wang, Jiang1 ; Zhang, Lei1; Jiang, Hualiang1,2; Liu, Hong1
|
| 刊名 | CURRENT PHARMACEUTICAL DESIGN
 |
| 出版日期 | 2010-04 |
| 卷号 | 16期号:10页码:1252-1259 |
| 关键词 | alpha,beta-diamino acids asymmetric synthesis methodological development |
| ISSN号 | 1381-6128 |
| DOI | 10.2174/138161210790945968 |
| 文献子类 | Review |
| 英文摘要 | alpha,beta-Diamino acids have attracted considerable attention recently due to their growing importance in pharmaceutical and biochemical research. For example, this special class of diamino acids has become the components of enzyme inhibitors, and has been incorporated into peptides which are used to modulate secondary and tertiary structural conformations. Although their widely occurrence in nature, optically active alpha,beta-diamino acids are hard to isolate and purify from available natural resources on large scale. Therefore, their asymmetric synthesis becomes a great interest for organic and medicinal chemists. However, there still exist great challenges for enantioselective synthesis of alpha,beta-diamino acids, especially those with two vicinal chiral centers. This review highlights the recent promising methodologies for enantioselective synthesis of alpha,beta-diamino acids, with special emphasis on catalytic asymmetric reactions, as well as methods for natural chiral compound derivatization, and chiral auxiliaries. |
| WOS关键词 | ASYMMETRIC MANNICH REACTIONS ; BETA-AMINO ACIDS ; ALPHA-AMINO ; P-TOLYLSULFINIMINES ; CHIRAL 1,2-DIAMINES ; 2,3-DIAMINO ACIDS ; LARGE-SCALE ; SIDE-CHAIN ; IN-SITU ; IMINES |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; International Collaboration Projects[20720102040] ; 863 Hi-Tech Program of China[2006AA020602] ; 863 Hi-Tech Program of China[2006AA10A201] ; National S&T Major Projects[2009ZX09301-001] ; National S&T Major Projects[2009ZX09501-001] ; National S&T Major Projects[2009ZX09501-010] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000275930100010 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278930]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Discovery & Design, State Key Lab Drug Res,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jiang,Zhang, Lei,Jiang, Hualiang,et al. Most Efficient Routes for the Synthesis of alpha,beta-Diamino Acid-Derived Compounds[J]. CURRENT PHARMACEUTICAL DESIGN,2010,16(10):1252-1259. |
| APA | Wang, Jiang,Zhang, Lei,Jiang, Hualiang,&Liu, Hong.(2010).Most Efficient Routes for the Synthesis of alpha,beta-Diamino Acid-Derived Compounds.CURRENT PHARMACEUTICAL DESIGN,16(10),1252-1259. |
| MLA | Wang, Jiang,et al."Most Efficient Routes for the Synthesis of alpha,beta-Diamino Acid-Derived Compounds".CURRENT PHARMACEUTICAL DESIGN 16.10(2010):1252-1259. |
入库方式： OAI收割
来源：上海药物研究所
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