Determination of melamine and cyanuric acid in human urine by a liquid chromatography tandem mass spectrometry
文献类型：期刊论文
| 作者 | Zhang, Mengqi2; Li, Shuijun1,2; Yu, Chengyin3,4; Liu, Gangyi2; Jia, Jingying2; Lu, Chuan2; He, Jian5; Ma, Yinghua4; Zhu, Jianmin2; Yu, Chen2 |
| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2010-03-15 |
| 卷号 | 878期号:9-10页码:758-762 |
| 关键词 | Melamine Cyanuric acid Liquid chromatography tandem mass spectrometry Human urine |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2010.01.020 |
| 文献子类 | Article |
| 英文摘要 | Melamine was found to be the etiological factor for the urinary stones epidemic in infants and young children in China in 2008. Urine level of melamine and its analog cyanuric acid may be useful markers for the evaluation of toxic effects. Liquid chromatography tandem mass spectrometry methods for the individual determination of melamine and cyanuric acid in human urine are described. Using isotope labeled internal standards during liquid-liquid extraction, the method was fully validated by verifying specificity, linearity, LLOQ Ultra- and inter-assay precision and accuracy, matrix effect, recovery and stability. Calibration curves with good linearity (r = 0.9999) over the concentration range from 10 to 5000 ng/ml, intra-assay precision <10% and inter-assay precision <15%, accuracy between 93.0 and 111.6% were obtained with multiple reaction monitoring mode for melamine and cyanuric acid in human urine. The methods were successfully applied to the analysis of urine samples collected from 86 infants and 110 adults. (C) 2010 Published by Elsevier B.V. |
| WOS关键词 | CATS ; DOGS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000276125100005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278945]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Chen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China; 2.Shanghai Xuhui Cent Hosp, Cent Lab, Shanghai 200031, Peoples R China; 3.Shanghai Univ Chinese Tradit Med, Coll Chinese Tradit Med, Shanghai, Peoples R China; 4.London Metropolitan Univ, Sch Hlth & Human, London, England; 5.Chinese Acad Med Sci, Ctr Clin Lab Dev, Beijing 100037, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Mengqi,Li, Shuijun,Yu, Chengyin,et al. Determination of melamine and cyanuric acid in human urine by a liquid chromatography tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2010,878(9-10):758-762. |
| APA | Zhang, Mengqi.,Li, Shuijun.,Yu, Chengyin.,Liu, Gangyi.,Jia, Jingying.,...&Yu, Chen.(2010).Determination of melamine and cyanuric acid in human urine by a liquid chromatography tandem mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,878(9-10),758-762. |
| MLA | Zhang, Mengqi,et al."Determination of melamine and cyanuric acid in human urine by a liquid chromatography tandem mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 878.9-10(2010):758-762. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。