Huperzine A Improves Chronic Inflammation and Cognitive Decline in Rats With Cerebral Hypoperfusion
文献类型：期刊论文
| 作者 | Wang, Juan; Zhang, Hai Yan; Tang, Xi Can |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2010-03 |
| 卷号 | 88期号:4页码:807-815 |
| 关键词 | cerebral hypoperfusion huperzine A chronic hypoxia inflammation white matter |
| ISSN号 | 0360-4012 |
| DOI | 10.1002/jnr.22237 |
| 文献子类 | Article |
| 英文摘要 | Chronic cerebral hypoperfusion has been suggested to contribute to the progression of dementia. Inflammation and white matter lesion (WML) are involved in the pathologic process. This study investigated whether huperzine A, a natural acetylcholinesterase (AChE) inhibitor, has beneficial effects on long-lasting inflammation as well as cognitive impairment in a rat model of cerebral hypoperfusion and how it plays these roles. Chronic cerebral hypoperfusion was induced by occlusion of bilateral common carotid arteries (two-vessel occlusion; 2VO). Huperzine A was initially given 150 min after 2VO and daily for 3, 7, 14, and 28 days. Learning and memory dysfunction as tested by Morris water maze performance was observed in 2VO-operated rats and was significantly improved by huperzine A treatment. WML and activation staining of immune cells were evaluated by Kluver-Barrera (KB) and immunohistochemistry, respectively. Myelin damage and increased immunostains were found in optic tract at all indicated days. Huperzine A treatment significantly ameliorated all these phenomena Moreover, huperzine A also suppressed overexpression of the inflammatory factor tumor necrosis factor-alpha (TNF-alpha) and overphosphorylation of JNK and p38 mitogen-activated protein kinases (MAPKs) in a cell model of chronic hypoxia Preincubation with mecamylamine (MEC), a nicotinic acetylcholine receptor (nAChR) antagonist, for 30 min before hypoxia notably reversed the effects of huperzine A on TNF-alpha production and MAPKs phosphorylation. In conclusion, delayed and chronic administration of huperzine A could protect against 2VO-induced cognitive impairment, which might be related to its beneficial effects on WML, and the nAChR-dependent cholinergic anti-inflammation pathway plays an important role. (C) 2009 Wiley-Liss, Inc. |
| WOS关键词 | CHOLINERGIC ANTIINFLAMMATORY PATHWAY ; CAROTID-ARTERY OCCLUSION ; WHITE-MATTER DAMAGE ; OXYGEN-GLUCOSE DEPRIVATION ; P38 MAP KINASE ; ALZHEIMERS-DISEASE ; CHOLINESTERASE-INHIBITORS ; MICROGLIAL ACTIVATION ; VASCULAR DEMENTIA ; ACETYLCHOLINESTERASE INHIBITORS |
| 资助项目 | Ministry of Science and Technology of China[2004CB518907] ; National Natural Science Foundation of China[30801402] ; Chinese Academy of Sciences[SIMM0709QN-12] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000274172400011 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278968]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Hai Yan |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Juan,Zhang, Hai Yan,Tang, Xi Can. Huperzine A Improves Chronic Inflammation and Cognitive Decline in Rats With Cerebral Hypoperfusion[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2010,88(4):807-815. |
| APA | Wang, Juan,Zhang, Hai Yan,&Tang, Xi Can.(2010).Huperzine A Improves Chronic Inflammation and Cognitive Decline in Rats With Cerebral Hypoperfusion.JOURNAL OF NEUROSCIENCE RESEARCH,88(4),807-815. |
| MLA | Wang, Juan,et al."Huperzine A Improves Chronic Inflammation and Cognitive Decline in Rats With Cerebral Hypoperfusion".JOURNAL OF NEUROSCIENCE RESEARCH 88.4(2010):807-815. |
入库方式： OAI收割
来源：上海药物研究所
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