Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones
文献类型：期刊论文
| 作者 | Zhou, Yu2 ; Zhai, Yun2; Ji, Xun1,2; Liu, Guannan2; Feng, Enguang2; Ye, Deju2; Zhao, Linxiang1; Jiang, Hualiang2; Liu, Hong2
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| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
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| 出版日期 | 2010-02 |
| 卷号 | 352期号:2-3页码:373-378 |
| 关键词 | alkynes gold pyrrolo-/pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones tandem reactions |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.200900724 |
| 文献子类 | Article |
| 英文摘要 | A highly efficient method has been developed for the one-pot synthesis of multi-ring heterocyclic compounds Such as pyrrolo-/pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones from o-aminobenzyl alcohols via a gold(I)-catalyzed tandem coupling/cyclization reaction. Significantly, the strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic molecular architectures in which two new C-N bonds and one C-O bond are formed in a one-pot reaction operation from two simple starting materials. Moreover, a broad spectrum Of Substrates can participate in the process effectively to produce the desired products in good yields. |
| WOS关键词 | GOLD-CATALYZED CYCLOISOMERIZATIONS ; ROOM-TEMPERATURE ; STEREOCENTERS ; CYCLIZATION ; CASCADE ; ALKYNES ; 1,5-ENYNES ; FRAMEWORK ; LACTONES ; ENYNES |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; National ST Major Project[2009ZX09301-001] ; National ST Major Project[2009ZX09501-001] ; 863 Hi-Tech Program of China[2006AA020602] ; 863 Hi-Tech Program of China[2006AA10A201] ; Shanghai Postdoctoral Science Foundation[09R21418000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000275235800019 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278975]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Yu,Zhai, Yun,Ji, Xun,et al. Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones[J]. ADVANCED SYNTHESIS & CATALYSIS,2010,352(2-3):373-378. |
| APA | Zhou, Yu.,Zhai, Yun.,Ji, Xun.,Liu, Guannan.,Feng, Enguang.,...&Liu, Hong.(2010).Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones.ADVANCED SYNTHESIS & CATALYSIS,352(2-3),373-378. |
| MLA | Zhou, Yu,et al."Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones".ADVANCED SYNTHESIS & CATALYSIS 352.2-3(2010):373-378. |
入库方式： OAI收割
来源：上海药物研究所
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