Tanshinone IIA Increases mRNA Expression of Efflux Transporters in Cultured Human Intestinal Cell
文献类型：期刊论文
| 作者 | Yin, Ying1,2; Yang, Min1; Wang, Yanhui1; Liu, Xuan1; Wu, Wanying1 ; Guan, Shuhong1; Guo, De-An1; Cui, Yajun2; Jiang, Baohong1
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| 刊名 | AMERICAN JOURNAL OF CHINESE MEDICINE
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| 出版日期 | 2010 |
| 卷号 | 38期号:5页码:995-1004 |
| 关键词 | Tanshinone IIA Caco-2 Cell Transporter Bioavailability |
| ISSN号 | 0192-415X |
| DOI | 10.1142/S0192415X1000841X |
| 文献子类 | Article |
| 英文摘要 | Tanshinone IIA (TSNIIA) is the major active component of Salvia miltorrhiza, which is used in treatment of cardiovascular and cerebrovascular diseases traditionally in China. However, the low bioavailability of TSNIIA limits its clinical usage. To reveal the mechanism relating the absorption of TSNIIA, we detected the expression of efflux transporters in Caco-2 cells under the stimulation of TSNIIA. TSNIIA was purified and above 98% purity was confirmed by high-performance liquid chromatography. The expression of nine efflux transporters including BCRP, hPepT1, MCT and MRP1-6 in Caco-2 were verified by reverse transcription polymerase chain reaction, and the up-regulation of TSNIIA on the expression of these transporters was found by reverse transcription real-time polymerase chain reaction. These results indicate that the low bioavailability of TSNIIA is partially due to its up-regulation on efflux transporters. |
| WOS关键词 | RESISTANCE ASSOCIATED PROTEINS ; ORAL-DRUG ABSORPTION ; ABC TRANSPORTERS ; CACO-2 ; PERMEABILITY ; BLOOD ; INHIBITORS ; DELIVERY ; BARRIER ; MUSCLE |
| 资助项目 | National S & T major special project for new innovative drug[2009ZX09308-005] ; National S & T major special project for new innovative drug[2009ZX09102-122] ; National S & T major special project for new innovative drug[2009ZX090304-002] ; National S & T major special project for new innovative drug[2009ZX09311-001] ; National S & T major special project for new innovative drug[2009ZX09502-020] ; State Key Laboratory of Natural and Biomimetic Drugs[K20090209] |
| WOS研究方向 | Integrative & Complementary Medicine ; General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000281576800015 |
| 出版者 | WORLD SCIENTIFIC PUBL CO PTE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279000]  |
| 专题 | 上海中药现代化研究中心 成果转移转化处 |
| 通讯作者 | Cui, Yajun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Ying,Yang, Min,Wang, Yanhui,et al. Tanshinone IIA Increases mRNA Expression of Efflux Transporters in Cultured Human Intestinal Cell[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2010,38(5):995-1004. |
| APA | Yin, Ying.,Yang, Min.,Wang, Yanhui.,Liu, Xuan.,Wu, Wanying.,...&Jiang, Baohong.(2010).Tanshinone IIA Increases mRNA Expression of Efflux Transporters in Cultured Human Intestinal Cell.AMERICAN JOURNAL OF CHINESE MEDICINE,38(5),995-1004. |
| MLA | Yin, Ying,et al."Tanshinone IIA Increases mRNA Expression of Efflux Transporters in Cultured Human Intestinal Cell".AMERICAN JOURNAL OF CHINESE MEDICINE 38.5(2010):995-1004. |
入库方式： OAI收割
来源：上海药物研究所
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