Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton
文献类型：期刊论文
| 作者 | Li, Wei3; Tao, Yi-Min1; Tang, Yun2; Xu, Xue-Jun1; Chen, Jie1; Fu, Wei3; Wang, Xing-Hai3; Chao, Bo3; Sheng, Wei3; Xie, Qiong3 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:1页码:418-421 |
| 关键词 | mu Opioid agonists Selective ligands Oripavines |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2009.07.119 |
| 文献子类 | Article |
| 英文摘要 | Unexpected substituent on the well-known morphine skeleton is described to be account for highly selective and potent l opioid ligands, which is strongly connected to substituted aromatic groups on this omitted 8 alpha-position. (C) 2009 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DIELS-ALDER REACTIONS ; MOLECULAR REARRANGEMENTS ; THEBAINE GROUP ; COMPUTATIONAL APPROACH ; OPIUM-ALKALOIDS ; ANALGESICS ; ADDUCTS ; CHEMISTRY ; ANALOGS |
| 资助项目 | Doctoral Fund of the Ministry of Education of China[20070246088] ; Shanghai Municipal Health Bureau[2007089] ; Shanghai Natural Science Foundation[08ZR1401500] ; Ministry of Science and Technology of China[G2003CB515400] ; National Natural Science Foundation of China[30425002] ; Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000272935600094 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279002]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Qiu, Zhui-Bai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Wei,Tao, Yi-Min,Tang, Yun,et al. Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(1):418-421. |
| APA | Li, Wei.,Tao, Yi-Min.,Tang, Yun.,Xu, Xue-Jun.,Chen, Jie.,...&Liu, Jing-Gen.(2010).Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(1),418-421. |
| MLA | Li, Wei,et al."Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.1(2010):418-421. |
入库方式： OAI收割
来源：上海药物研究所
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