Magnesium lithospermate B protects cardiomyocytes from ischemic injury via inhibition of TAB1-p38 apoptosis signaling
文献类型：期刊论文
| 作者 | Du, Chang-Sheng1; Yang, Rui-Fang2; Song, Shu-Wei2; Wang, Yi-Ping3 ; Kang, Jiu-Hong1; Zhang, Ru1; Su, Ding-Feng2; Xie, Xin1,3
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| 刊名 | FRONTIERS IN PHARMACOLOGY
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| 出版日期 | 2010 |
| 卷号 | 1 |
| 关键词 | magnesium lithospermate B ischemia apoptosis p38 TAB1 |
| ISSN号 | 1663-9812 |
| DOI | 10.3389/fphar.2010.00111 |
| 文献子类 | Article |
| 英文摘要 | Danshen has been used in traditional Chinese medicine for hundreds of years to treat cardiovascular diseases. However, its precise cardioprotective components and the underlying mechanism are still unclear. In the present study, we demonstrated that in a rat model of acute myocardial infarction, the treatment with magnesium lithospermate B (MLB), the representative component of phenolic acids in Danshen, significantly reduced the infarct size and the blood lactate dehydrogenase level. In contrast, tanshinone IIA, the representative component of lipophilic tanshinones in Danshen, had no such protective effects. Moreover, in the simulated ischemia cell model, MLB treatment considerably increased the cell viability and reduced the sub-G1 population and the apoptotic nuclei, indicating its anti-apoptotic effect. Further mechanism study revealed that the ischemia-induced p38 phosphorylation was abolished by MLB treatment. Interestingly, MLB specifically inhibited the TGF beta-activated protein kinase 1-binding protein 1 (TAB1) mediated p38 phosphorylation through disrupting the interaction between TAB1 and p38, but it did not affect the mitogen-activated protein kinase 3/6 mediated p38 phosphorylation. In conclusion, the present study identifies MLB as an active component of Danshen in protecting cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling. These results indicate TAB1-p38 interaction as a putative drug target in treating ischemic heart diseases. |
| 资助项目 | National Natural Science Foundation of China[90713047] ; Ministry of Science and Technology of China[2008DFB30150] ; Shanghai Municipal Commission for Science and Technology[08410703500] ; Shanghai Municipal Commission for Science and Technology[08431910100] ; Shanghai Municipal Commission for Science and Technology[09PJ1410000] ; Shanghai Postdoctoral Science Foundation[06R214161] ; Shanghai Key Laboratory of Signaling and Disease Research[09DZ2260100] ; Roche RRDCC Basic Research[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000209177100011 |
| 出版者 | FRONTIERS RESEARCH FOUNDATION |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279018]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Su, Ding-Feng |
| 作者单位 | 1.Tongji Univ, Lab Receptor Based BioMed, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China; 2.Second Mil Med Univ, Dept Pharmacol, Sch Pharm, Shanghai 200433, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Chang-Sheng,Yang, Rui-Fang,Song, Shu-Wei,et al. Magnesium lithospermate B protects cardiomyocytes from ischemic injury via inhibition of TAB1-p38 apoptosis signaling[J]. FRONTIERS IN PHARMACOLOGY,2010,1. |
| APA | Du, Chang-Sheng.,Yang, Rui-Fang.,Song, Shu-Wei.,Wang, Yi-Ping.,Kang, Jiu-Hong.,...&Xie, Xin.(2010).Magnesium lithospermate B protects cardiomyocytes from ischemic injury via inhibition of TAB1-p38 apoptosis signaling.FRONTIERS IN PHARMACOLOGY,1. |
| MLA | Du, Chang-Sheng,et al."Magnesium lithospermate B protects cardiomyocytes from ischemic injury via inhibition of TAB1-p38 apoptosis signaling".FRONTIERS IN PHARMACOLOGY 1(2010). |
入库方式： OAI收割
来源：上海药物研究所
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