New oxidized sterols from Aspergillus awamori and the endo-boat conformation adopted by the cyclohexene oxide system
文献类型：期刊论文
| 作者 | Gao, Hao1,2,3; Hong, Kui4; Chen, Guo-Dong1,2; Wang, Chuan-Xi1,2; Tang, Jin-Shan1,2; Yu, Yang5; Jiang, Miao-Miao5; Li, Man-Mei1,2; Wang, Nai-Li5; Yao, Xin-Sheng1,2,5 |
| 刊名 | MAGNETIC RESONANCE IN CHEMISTRY
 |
| 出版日期 | 2010-01 |
| 卷号 | 48期号:1页码:38-43 |
| 关键词 | H-1 NMR C-13 NMR 2D NMR Aspergillus awamori mangrove fungus 5 alpha,6 alpha-epoxy sterols cytotoxic activity endo-boat conformation cyclohexene oxide |
| ISSN号 | 0749-1581 |
| DOI | 10.1002/mrc.2536 |
| 文献子类 | Article |
| 英文摘要 | Two new oxidized sterols 1 and 2 were obtained from the active fraction of a mangrove fungus Aspergillus awamori isolated from the soils around the mangrove plant Acrostichum speciosum. Their structures were elucidated using spectroscopic methods as 22E-7 alpha-methoxy-5 alpha,6 alpha-epoxyergosta- 8(14),22-dien-3 beta-ol (1) and 22E-3 beta-hydroxy-5 alpha,6 alpha,8 alpha,14 alpha-diepoxyergosta-22-en-7-one (2). The NMR data and complete assignments for both DMSO-d(6) and CDCl3 were given. Their cytotoxic activity against A549 cell line was evaluated. Furthermore, the detailed conformation analysis for ring B (cyclohexene oxide system) of sterol 1 was given on the basis of NOEs. The endo-boat conformation was considered as the preferred conformation for ring B rather than half-chair conformation. Copyright (c) 2009 John Wiley & Sons, Ltd. |
| WOS关键词 | MAGNETIC-RESONANCE ; C-13 NMR ; 9,10-DIHYDROANTHRACENE ; SPECTROSCOPY ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[U0633008] ; National Basic Research Program of China[2009CB522300/2009CB522302] ; National Special Funds of Science and Technology[2008ZX09401-05] ; National Special Funds of Science and Technology[2009ZX09302-004] ; State Key Laboratory of Drug Research[SIMM0812KF-02] |
| WOS研究方向 | Chemistry ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000273773500006 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279043]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Yao, Xin-Sheng |
| 作者单位 | 1.Jinan Univ, Inst Tradit Chinese Med & Nat Products, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China; 2.Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Tradit Chinese Med & New Drugs Res, Guangzhou 510632, Guangdong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Inst Tropicol Biosci & Biotechnol, Haikou 571101, Peoples R China; 5.Shenyang Pharmaceut Univ, Tradit Chinese Med Coll, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Hao,Hong, Kui,Chen, Guo-Dong,et al. New oxidized sterols from Aspergillus awamori and the endo-boat conformation adopted by the cyclohexene oxide system[J]. MAGNETIC RESONANCE IN CHEMISTRY,2010,48(1):38-43. |
| APA | Gao, Hao.,Hong, Kui.,Chen, Guo-Dong.,Wang, Chuan-Xi.,Tang, Jin-Shan.,...&Yao, Xin-Sheng.(2010).New oxidized sterols from Aspergillus awamori and the endo-boat conformation adopted by the cyclohexene oxide system.MAGNETIC RESONANCE IN CHEMISTRY,48(1),38-43. |
| MLA | Gao, Hao,et al."New oxidized sterols from Aspergillus awamori and the endo-boat conformation adopted by the cyclohexene oxide system".MAGNETIC RESONANCE IN CHEMISTRY 48.1(2010):38-43. |
入库方式： OAI收割
来源：上海药物研究所
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