Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells
文献类型：期刊论文
| 作者 | Li, Xin1; Qian, Shijing2; He, Qiaojun2; Yang, Bo2; Li, Jia3 ; Hu, Yongzhou1
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 8期号:16页码:3627-3630 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c004344c |
| 文献子类 | Article |
| 英文摘要 | A new fluorescent turn-on probe for the rapid optical sensing of thiols has been designed and synthesized. The probe displays high on/off signal ratios and high selectivity towards thiols. The potential of the probe as a biosensor for thiols was demonstrated by imaging of thiols in living cells. |
| WOS关键词 | DISTYRYL-BORADIAZAINDACENES ; SPECTROSCOPIC PROPERTIES ; OXIDATIVE STRESS ; BODIPY DYES ; HOMOCYSTEINE ; DERIVATIVES ; PROTEINS ; CYSTEINE ; LIBRARY ; DISEASE |
| 资助项目 | National Natural Science Foundation of China[30901858] ; National Key Tech Project for Major Creation of New drugs[2009ZX09501-003] ; China Postdoctoral Science Foundation[20090461390] ; State Key Laboratory of Drug Research[SIMM1004KF-13] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000280527500006 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279053]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 国家新药筛选中心 |
| 通讯作者 | Hu, Yongzhou |
| 作者单位 | 1.Zhejiang Univ, ZJU ENS Joint Lab Med Chem, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 2.Zhejiang Univ, Inst Pharmacol & Toxicol, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xin,Qian, Shijing,He, Qiaojun,et al. Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2010,8(16):3627-3630. |
| APA | Li, Xin,Qian, Shijing,He, Qiaojun,Yang, Bo,Li, Jia,&Hu, Yongzhou.(2010).Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells.ORGANIC & BIOMOLECULAR CHEMISTRY,8(16),3627-3630. |
| MLA | Li, Xin,et al."Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells".ORGANIC & BIOMOLECULAR CHEMISTRY 8.16(2010):3627-3630. |
入库方式： OAI收割
来源：上海药物研究所
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