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Synthesis of N-11-anchoring biotinylated artemisinin derivatives and their preliminary biological assessment

文献类型：期刊论文

作者Pan QiYu2,3; Wang ShaoZhong2; Lu JinJian1; Meng LingHua1; Yao ZhuJun2,3
刊名SCIENCE CHINA-CHEMISTRY
出版日期2010-01
卷号53期号:1页码:119-124
关键词artemisinin endoperoxide biotinylated derivative synthesis anticancer activity
ISSN号1674-7291
DOI10.1007/s11426-010-0009-z
文献子类Article
英文摘要Unique endoperoxide moiety of artemisinin and its derivatives has been considered the functionality exhibiting highly potent antimalarial and anticancer activities. To investigate the mechanisms of their biological actions, development of suitable molecular probes including biotinylated derivatives is of extreme significance. The synthesis and preliminary biological assessment of four new biotinylated artemisinin derivatives have been reported in this work.
WOS关键词ANTIMALARIAL-DRUG ; NITRATION ; MECHANISM ; EFFICACY
资助项目National Natural Science Foundation of China[20672128] ; National Natural Science Foundation of China[90713044] ; National Natural Science Foundation of China[30701026] ; CAS[KSCX2-YW-R23]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000276547200014
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/279059]  
专题药理学第一研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Meng LingHua
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Nanjing Univ, Sch Chem & Chem Engn, NNLM, Nanjing 210093, Peoples R China;
3.Univ Sci & Technol China, Dept Chem, Joint Lab Green Chem, Hefei 230026, Peoples R China
推荐引用方式
GB/T 7714		 Pan QiYu,Wang ShaoZhong,Lu JinJian,et al. Synthesis of N-11-anchoring biotinylated artemisinin derivatives and their preliminary biological assessment[J]. SCIENCE CHINA-CHEMISTRY,2010,53(1):119-124.
APA Pan QiYu,Wang ShaoZhong,Lu JinJian,Meng LingHua,&Yao ZhuJun.(2010).Synthesis of N-11-anchoring biotinylated artemisinin derivatives and their preliminary biological assessment.SCIENCE CHINA-CHEMISTRY,53(1),119-124.
MLA Pan QiYu,et al."Synthesis of N-11-anchoring biotinylated artemisinin derivatives and their preliminary biological assessment".SCIENCE CHINA-CHEMISTRY 53.1(2010):119-124.

入库方式： OAI收割

来源：上海药物研究所

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