SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo
文献类型：期刊论文
| 作者 | Hou, Li-Fei2; He, Shi-Jun2 ; Wang, Jun-Xia2; Yang, Yang3; Zhu, Feng-Hua2; Zhou, Yu2; He, Pei-Lan2; Zhang, Yu; Yang, Yi-Fu3; Li, Ying1
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| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2009-12 |
| 卷号 | 9期号:13-14页码:1509-1517 |
| 关键词 | SM934 Artemisinin TCR IL-2 T lymphocytes Apoptosis Akt Delayed type hypersensitivity |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2009.09.003 |
| 文献子类 | Article |
| 英文摘要 | In the present study, we investigated the immunosuppressive effects and underlying mechanisms of aminoarteether maleate (SM934), a derivative of artemisinin, against T cell activation in vitro and in vivo. In vitro, SM934 significantly inhibited the proliferation of splenocytes induced by concanavalin A (Con A), lipopolysaccharide (LPS), mixed lymphocyte reaction (MLR), and anti-CD3 plus anti-CD28 (anti-CD3/28). SM934 significantly inhibited interferon (IFN)-gamma production and CD4(+) T cell division stimulated by anti-CD3/28. SM934 also promoted apoptosis of CD69(+) population in CD4(+) T cells stimulated by anti-CD3/28. Furthermore, SM934 inhibited interleukin (IL)-2 mediated proliferation and survival through blocking Akt phosphorylation in activated T cells. In ovalbumin (OVA)-immunized mice, oral administration of SM934 suppressed OVA-specific T cell proliferation and IFN-gamma production. SM934 treatment also significantly inhibited the sheep red blood cell (SRBC)-induced delayed type hypersensitivity (DTH) reactions in mice. Taken together, SM934 showed potent immunosuppressive activities in vitro and in vivo. Our results demonstrated that SM934 might be a potential therapeutic agent for immune-related diseases. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS关键词 | T-CELL PROLIFERATION ; ARTEMISININ DERIVATIVES ; INTERLEUKIN-2 ; ACTIVATION ; APOPTOSIS ; IL-2 ; SURVIVAL ; TRANSPLANTATION ; TRANSDUCTION ; ARTESUNATE |
| 资助项目 | Shanghai Science and Technology Committee[08XD14053] ; Shanghai Science and Technology Committee[06DZ19006] ; Shanghai Science and Technology Committee[08DZ1980200] ; Chinese Academy of Science[SIMM0709QN-01] ; national key scientific and technological project[2009ZX09102-019] |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000272291000010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279075]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Li, Ying |
| 作者单位 | 1.Chinese Acad Sci, Lab Synthet Chem, Shanghai Inst Mat Med, Dept Synthet Chem, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Li-Fei,He, Shi-Jun,Wang, Jun-Xia,et al. SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2009,9(13-14):1509-1517. |
| APA | Hou, Li-Fei.,He, Shi-Jun.,Wang, Jun-Xia.,Yang, Yang.,Zhu, Feng-Hua.,...&Zuo, Jian-Ping.(2009).SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo.INTERNATIONAL IMMUNOPHARMACOLOGY,9(13-14),1509-1517. |
| MLA | Hou, Li-Fei,et al."SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo".INTERNATIONAL IMMUNOPHARMACOLOGY 9.13-14(2009):1509-1517. |
入库方式： OAI收割
来源：上海药物研究所
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