Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet
文献类型：期刊论文
| 作者 | Guo, Hong-xia; Liu, Dai-hua; Ma, Ying; Liu, Jin-feng; Wang, Ying; Du, Zhi-yan; Wang, Xin ; Shen, Jing-kang; Peng, Hong-li
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2009-11 |
| 卷号 | 30期号:11页码:1505-1512 |
| 关键词 | baicalin hepatic steatosis AMPK tumor necrosis factor alpha |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2009.150 |
| 文献子类 | Article |
| 英文摘要 | Aim: Baicalin, one of the major flavonoids in Scutellaria baicalensis, possesses antioxidant and anti-inflammatory properties. However, the effects of baicalin on metabolic disorders and hepatic steatosis have not been investigated. Methods: Body weight was examined in high-fat diet (HFD)-fed rats with or without baicalin treatment. At the end of the experiment, serum biochemical parameters, liver histology and lipid profile were analyzed to assess whether the animals were suffering from metabolic disorders or hepatic steatosis. In the liver, the phosphorylation of AMP activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) and the gene expression of some enzymes involved in lipogenesis were examined. The effects of baicalin on the phosphorylation of AMPK and lipid accumulation induced by high glucose in human hepatoma HepG2 cells were also examined. Results: Baicalin (80 mg/kg) administered ip for 16 weeks suppressed body weight gain in HFD-fed rats. Weight reduction was accompanied by the reduction of visceral fat mass. Baicalin significantly decreased the elevated serum cholesterol, free fatty acid and insulin concentrations caused by the HFD. Baicalin also suppressed systemic inflammation by reducing the serum level of tumor necrosis factor a. Baicalin reduced hepatic lipid accumulation, enhanced the phosphorylation of AMPK and ACC and down-regulated genes involved in lipogenesis, including fatty acid synthase and its upstream regulator SREBP-1c. In HepG2 cells, baicalin (5 and 10 mu mol/L) increased the phosphorylation of AMPK and decreased lipid accumulation following the addition of high glucose. Conclusion: Our study suggests that baicalin might have beneficial effects on the development of hepatic steatosis and obesity-related disorders by targeting the hepatic AMPK. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; HUMAN HEPG2 CELLS ; OREN-GEDOKU-TO ; LIVER-DISEASE ; SCUTELLARIA-BAICALENSIS ; NONALCOHOLIC STEATOHEPATITIS ; LIPID-ACCUMULATION ; MICE ; METFORMIN ; ATHEROSCLEROSIS |
| 资助项目 | National Natural Science Foundation of China[30672467] ; Ministry of Science and Technology[2007AA02Z308] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3758767 |
| WOS记录号 | WOS:000271953500004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279083]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Peng, Hong-li |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Hong-xia,Liu, Dai-hua,Ma, Ying,et al. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet[J]. ACTA PHARMACOLOGICA SINICA,2009,30(11):1505-1512. |
| APA | Guo, Hong-xia.,Liu, Dai-hua.,Ma, Ying.,Liu, Jin-feng.,Wang, Ying.,...&Peng, Hong-li.(2009).Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet.ACTA PHARMACOLOGICA SINICA,30(11),1505-1512. |
| MLA | Guo, Hong-xia,et al."Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet".ACTA PHARMACOLOGICA SINICA 30.11(2009):1505-1512. |
入库方式： OAI收割
来源：上海药物研究所
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