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A new kalihinol diterpene from the Hainan sponge Acanthella sp.

文献类型：期刊论文

作者Sun, Ji-Zheng1; Chen, Kao-Shan1; Yao, Li-gong2; Liu, Hai-Li2; Guo, Yue-Wei2
刊名ARCHIVES OF PHARMACAL RESEARCH
出版日期2009-11
卷号32期号:11页码:1581-1584
关键词Sponge Acanthella sp. Diterpenoid Kalihinol
ISSN号0253-6269
DOI10.1007/s12272-009-2110-4
文献子类Article
英文摘要A new kalihinol diterpene, 10-epi-kalihinol X (1), together with two known related diterpenes (2 and 3), and two sesquiterpenes (4 and 5) were isolated from the Hainan sponge Acanthella sp. The structure of the new compound was elucidated on the basis of the detailed analysis of its spectroscopic data and by comparison of its NMR data with those of structurally related compounds. Compounds 1 and 3-5 exhibited in vitro moderate cytotoxicities against human lung adenocarcinoma cell line A549, with IC50 values of 9.30, 3.17, 2.44, and 1.98 A mu g/mL, respectively.
WOS关键词SOUTH CHINA SEA ; A-E ; SESQUITERPENES ; METABOLITES ; NUDIBRANCH ; CAVERNOSA
资助项目National Marine "863"Projects[2006AA09Z412] ; National Marine "863"Projects[2007AA09Z447] ; Natural Science Foundation of China[20572116] ; Natural Science Foundation of China[30730108] ; Natural Science Foundation of China[20721003] ; STCSM Projects[07XD14036] ; STCSM Projects[06DZ22028] ; CAS Key Project[KSCX2-YW-R-18]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000272017700011
出版者PHARMACEUTICAL SOC KOREA
源URL[http://119.78.100.183/handle/2S10ELR8/279088]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Guo, Yue-Wei
作者单位1.Shandong Univ, Coll Life Sci, Jinan 250100, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Sun, Ji-Zheng,Chen, Kao-Shan,Yao, Li-gong,et al. A new kalihinol diterpene from the Hainan sponge Acanthella sp.[J]. ARCHIVES OF PHARMACAL RESEARCH,2009,32(11):1581-1584.
APA Sun, Ji-Zheng,Chen, Kao-Shan,Yao, Li-gong,Liu, Hai-Li,&Guo, Yue-Wei.(2009).A new kalihinol diterpene from the Hainan sponge Acanthella sp..ARCHIVES OF PHARMACAL RESEARCH,32(11),1581-1584.
MLA Sun, Ji-Zheng,et al."A new kalihinol diterpene from the Hainan sponge Acanthella sp.".ARCHIVES OF PHARMACAL RESEARCH 32.11(2009):1581-1584.

入库方式： OAI收割

来源：上海药物研究所

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