Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats
文献类型：期刊论文
| 作者 | Hou, Yuan-yuan; Liu, Yao; Kang, Shuo; Yu, Chuan; Chi, Zhi-qiang ; Liu, Jing-gen
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2009-10 |
| 卷号 | 30期号:10页码:1385-1391 |
| 关键词 | NMDA receptors AMPA receptors hippocampus morphine withdrawal conditioned place aversion Rats, Sprague-Dawley microinjections |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2009.130 |
| 文献子类 | Article |
| 英文摘要 | Aim: To evaluate the role of glutamate receptors in the dorsal hippocampus (DH) in the motivational component of morphine withdrawal. Methods: NMDA receptor antagonist D-AP5 (5 mu g/0.5 mu L per side) or AMPA receptor antagonist NBQX (2 mu g/0.5 mu L per side) was microinjected into DH of rats. Conditioned place aversion (CPA) induced by naloxone- precipitated morphine withdrawal were assessed. Results: Preconditioning microinjection of D-AP5 or NBQX into the DH impaired the acquisition of CPA in acute morphine-dependent rats. However, intra-DH microinjection of D-AP5 or NBQX after conditioning but before the testing session had no effect on the expression of CPA. Conclusion: Our results suggest that NMDA and AMPA receptors in the dorsal hippocampus are involved in the acquisition, but not in the expression, of the negative motivational components of acute morphine withdrawal in rats. |
| WOS关键词 | LONG-TERM POTENTIATION ; NMDA RECEPTORS ; CENTRAL NUCLEUS ; MEMORY ; AMYGDALA ; MECHANISMS ; PLASTICITY ; PREFERENCE ; ADDICTION ; NALOXONE |
| 资助项目 | Ministry of Science and Technology of China[G2003CB515400] ; Ministry of Science and Technology of China[2009CB522000] ; National Natural Science Foundation of China[30425002] ; Chinese Academy of Sciences[KSCXI/YW/R/68] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3739969 |
| WOS记录号 | WOS:000270733600002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279104]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Jing-gen |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Yuan-yuan,Liu, Yao,Kang, Shuo,et al. Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats[J]. ACTA PHARMACOLOGICA SINICA,2009,30(10):1385-1391. |
| APA | Hou, Yuan-yuan,Liu, Yao,Kang, Shuo,Yu, Chuan,Chi, Zhi-qiang,&Liu, Jing-gen.(2009).Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats.ACTA PHARMACOLOGICA SINICA,30(10),1385-1391. |
| MLA | Hou, Yuan-yuan,et al."Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats".ACTA PHARMACOLOGICA SINICA 30.10(2009):1385-1391. |
入库方式： OAI收割
来源：上海药物研究所
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