Liquid chromatography/tandem mass spectrometry for the determination of changrolin in rat plasma: Application to a bioavailability study
文献类型：期刊论文
| 作者 | Yang, Ding1; Yu, Chen2; Li, Shuijun1,2; Liu, Gangyi2; Lu, Youli1; Wang, Yiping1
|
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2009-09-08 |
| 卷号 | 50期号:2页码:189-193 |
| 关键词 | Changrolin LC-MS/MS Rat plasma Bioavailability study Pharmacokinetics |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2009.04.010 |
| 文献子类 | Article |
| 英文摘要 | A sensitive and specific LC-CMS/MS method was developed for the quantification of changrolin, an antiarrhythmic drug, in rat plasma using tiapride as internal standard. Liquid-liquid extraction was employed for sample preparation and analyzed using a multiple reaction monitoring mode with electrospray positive ionization source. The calibration curve for changrolin was linear over the range 5-1600 ng/mL with coefficients of correlation >0.99. The intra- and inter-batch precision was less than 8.6%, and accuracy ranged from 94.6% to 104.5%. This validated LC-MS/MS method was successfully applied to a bioavailability study of oral and intravenous administration of changrolin with 20mg/kg dosage in SD rats. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS关键词 | DERIVATIVES |
| 资助项目 | National Basic Research Program of China[2009CB930300] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000267037700012 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279135]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Yiping |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Shanghai Xuhui Cent Hosp, Cent Lab, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Ding,Yu, Chen,Li, Shuijun,et al. Liquid chromatography/tandem mass spectrometry for the determination of changrolin in rat plasma: Application to a bioavailability study[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2009,50(2):189-193. |
| APA | Yang, Ding,Yu, Chen,Li, Shuijun,Liu, Gangyi,Lu, Youli,&Wang, Yiping.(2009).Liquid chromatography/tandem mass spectrometry for the determination of changrolin in rat plasma: Application to a bioavailability study.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,50(2),189-193. |
| MLA | Yang, Ding,et al."Liquid chromatography/tandem mass spectrometry for the determination of changrolin in rat plasma: Application to a bioavailability study".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 50.2(2009):189-193. |
入库方式： OAI收割
来源：上海药物研究所
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