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Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
文献类型：期刊论文
| 作者 | Hait, Nitai C.2,3; Allegood, Jeremy2,3; Maceyka, Michael2,3; Strub, Graham M.2,3; Harikumar, Kuzhuvelil B.2,3; Singh, Sandeep K.2,3; Luo, Cheng4,5,6 ; Marmorstein, Ronen4,5; Kordula, Tomasz2,3; Milstien, Sheldon1
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| 刊名 | SCIENCE
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| 出版日期 | 2009-09-04 |
| 卷号 | 325期号:5945页码:1254-1257 |
| ISSN号 | 0036-8075 |
| DOI | 10.1126/science.1176709 |
| 文献子类 | Article |
| 英文摘要 | The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) can act intracellularly independently of its cell surface receptors through unknown mechanisms. Sphingosine kinase 2 (SphK2), one of the isoenzymes that generates S1P, was associated with histone H3 and produced S1P that regulated histone acetylation. S1P specifically bound to the histone deacetylases HDAC1 and HDAC2 and inhibited their enzymatic activity, preventing the removal of acetyl groups from lysine residues within histone tails. SphK2 associated with HDAC1 and HDAC2 in repressor complexes and was selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription. Thus, HDACs are direct intracellular targets of S1P and link nuclear S1P to epigenetic regulation of gene expression. |
| WOS关键词 | MEDIATED PHOSPHORYLATION ; DEACETYLASE INHIBITORS ; SPHINGOSINE-KINASE-2 ; ACTIVATION ; FAMILY |
| 资助项目 | NIH[R37GM043880] ; NIH[R01CA61774] ; National Research Service Award[F30NSO58008] ; NIMH Intramural Research Program[00000000] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000269523200040 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279136]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Spiegel, Sarah |
| 作者单位 | 1.NIMH, NIH, Bethesda, MD 20892 USA 2.Virginia Commonwealth Univ, Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA; 3.Virginia Commonwealth Univ, Sch Med, Massey Canc Ctr, Richmond, VA 23298 USA; 4.Univ Penn, Dept Chem, Philadelphia, PA 19104 USA; 5.Univ Penn, Wistar Inst, Philadelphia, PA 19104 USA; 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Hait, Nitai C.,Allegood, Jeremy,Maceyka, Michael,et al. Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate[J]. SCIENCE,2009,325(5945):1254-1257. |
| APA | Hait, Nitai C..,Allegood, Jeremy.,Maceyka, Michael.,Strub, Graham M..,Harikumar, Kuzhuvelil B..,...&Spiegel, Sarah.(2009).Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate.SCIENCE,325(5945),1254-1257. |
| MLA | Hait, Nitai C.,et al."Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate".SCIENCE 325.5945(2009):1254-1257. |
入库方式： OAI收割
来源：上海药物研究所
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