Efficient Synthesis of alpha-Aryl-/Heteroaryl-Substituted beta-Amino Acids via Ni(II) Complex through the Suzuki Coupling Reaction
文献类型：期刊论文
| 作者 | Ding, Xiao1; Ye, Deju1; Liu, Fang1,2; Deng, Guanghui1; Liu, Guannan1; Luo, Xiaomin1 ; Jiang, Hualiang1; Liu, Hong1
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2009-08-07 |
| 卷号 | 74期号:15页码:5656-5659 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/jo900469d |
| 文献子类 | Article |
| 英文摘要 | We described a synthesis method by first using chloro-trimethylsilane as the activator to brominate the Ni(II) complex of the beta-alanine Schiff's base [beta-AlaNi(II)PABA] and developed it to prepare beta-amino acids 5. The procedure involves a Suzuki coupling reaction between boric acids and the bromoenone 2, followed by hydrogenation and hydrolysis. This is the first report of the application of the Ni (II) complex [beta-AlaNi(II)PABA], which represents an attractive route to afford alpha-aryl-/heteroaryl-substituted beta-amino acids. |
| WOS关键词 | ASYMMETRIC-SYNTHESIS ; BETA(2)-AMINO ACIDS ; CHIRAL AUXILIARY ; STEREOSELECTIVE-SYNTHESIS ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; International Collaboration Projects[2007DFB30370] ; International Collaboration Projects[20720102040] ; 863 Hi-Tech Program of China[2006AA020602] ; 863 Hi-Tech Program of China[2006AA020402] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000268480300080 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279162]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物发现与设计中心 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Ctr Drug Discovery & Design, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Xiao,Ye, Deju,Liu, Fang,et al. Efficient Synthesis of alpha-Aryl-/Heteroaryl-Substituted beta-Amino Acids via Ni(II) Complex through the Suzuki Coupling Reaction[J]. JOURNAL OF ORGANIC CHEMISTRY,2009,74(15):5656-5659. |
| APA | Ding, Xiao.,Ye, Deju.,Liu, Fang.,Deng, Guanghui.,Liu, Guannan.,...&Liu, Hong.(2009).Efficient Synthesis of alpha-Aryl-/Heteroaryl-Substituted beta-Amino Acids via Ni(II) Complex through the Suzuki Coupling Reaction.JOURNAL OF ORGANIC CHEMISTRY,74(15),5656-5659. |
| MLA | Ding, Xiao,et al."Efficient Synthesis of alpha-Aryl-/Heteroaryl-Substituted beta-Amino Acids via Ni(II) Complex through the Suzuki Coupling Reaction".JOURNAL OF ORGANIC CHEMISTRY 74.15(2009):5656-5659. |
入库方式： OAI收割
来源：上海药物研究所
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