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Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro
文献类型：期刊论文
| 作者 | Wang, Gui-Feng1 ; Shi, Li-Ping1; Ren, Yu-Dan1; Liu, Qun-Fang2; Liu, Hou-Fu3; Zhang, Ru-Jun2; Li, Zhuang5; Zhu, Feng-Hua1; He, Pei-Lan1; Tang, Wei1
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| 刊名 | ANTIVIRAL RESEARCH
 |
| 出版日期 | 2009-08 |
| 卷号 | 83期号:2页码:186-190 |
| 关键词 | Chlorogenic acid Quinic acid Caffeic acid Coffee crude extracts HBV |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2009.05.002 |
| 文献子类 | Article |
| 英文摘要 | Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS关键词 | ANTIVIRAL ACTIVITY ; COFFEE CONSUMPTION ; RISK ; EXTRACTS ; CELLS ; DERIVATIVES ; INHIBITION ; ORIGIN ; CANCER ; AGENTS |
| 资助项目 | National Basic Research Program of China[30672492] ; National Basic Research Program of China[30701033] ; National Basic Research Program of China[2005CB523403] |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000267999700012 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279166]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zuo, Jian-Ping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Nat Prod Chem, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Ctr Drug Metab & Pharmacokinet Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai, Peoples R China; 5.Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100037, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Gui-Feng,Shi, Li-Ping,Ren, Yu-Dan,et al. Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro[J]. ANTIVIRAL RESEARCH,2009,83(2):186-190. |
| APA | Wang, Gui-Feng.,Shi, Li-Ping.,Ren, Yu-Dan.,Liu, Qun-Fang.,Liu, Hou-Fu.,...&Zuo, Jian-Ping.(2009).Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.ANTIVIRAL RESEARCH,83(2),186-190. |
| MLA | Wang, Gui-Feng,et al."Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro".ANTIVIRAL RESEARCH 83.2(2009):186-190. |
入库方式： OAI收割
来源：上海药物研究所
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